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| Diagnostic value of thyroid cold nodules by using 99Tcm-HL91/99Tcm-MIBI imaging |
| YANG Fan, YUAN Wei-hong, ZHANG Yi, YANG Jian-xian, YUE Jiang-hong, LING Gang-bo |
| Department of Nuclear Medicine, the Second Affiliated Hospital of Kunming Medical University, Kunming 650101, China |
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Abstract Objective: To evaluate the diagnostic value of 99Tcm-HL91 and 99Tcm-MIBI imaging in thyroid cold nodules with the qualitative and semi-quantitative analysis. Methods: 103 patients with cold nodules underwent SPECT tumor imaging before operation. Thirty-five patients underwent 99Tcm-HL91 imaging, 68 patients underwent 99Tcm-MIBI imaging; and then comparing the qualitative and semi-quantitative analysis of the early and delayed images in the two groups. Results: The accuracy and specificity of 99Tcm-HL91 hypoxia imaging in the diagnosis of thyroid cold nodules were higher than 99Tcm-MIBI tumor imaging, there was a significant difference(P<0.001); the sensitivity of the two imaging methods had no significant difference. Conclusion: 99Tcm-HL91 imaging in differentiating malignant from benign thyroid cold nodules is more useful than 99Tcm-MIBI imaging.
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Received: 11 August 2009
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Corresponding Authors:
YUAN Wei-hong
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2010, Vol. 21 
