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| Evaluation the effect of simvastatin on vascular endothelial function by high frequency sonography in atherosclerotic rabbits |
| YANG Xin1, WANG Wei1, CAO Xia1, ZHENG Chun-mei1, MA Chun-yan2, REN Wei-dong2 |
| 1. Department of Physical Diagnosis, First Affiliated Hospital of Jiamusi University, Jiamusi Heilongjiang 154002, China;2. Department of Heart Function, First Affiliated Hospital of China Medical University, Shenyang 110001, China |
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Abstract Objective: To assess the effect of simvastatin on vascular endothelial function by high frequency sonography. Methods: Fifty rabbits were randomly divided into control group(A group) and atherosclerotic group(B group) and simvastatin group(C group). Endothelial dependent dilation(EDD) and non-endothelial dependent dilation(NEDD) were measured with high resolution sonography at different time. Results: After intervention of simvastatin, the blood lipid decreased, EDD function was obviously improved, and NEDD was improved after 12 weeks. There was significant difference between the two groups. Conclusions: Simvastatin can improve endothelial function. High frequency sonography can be used to assess the effect of drug therapy on endothelial function.
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Received: 29 December 2009
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Corresponding Authors:
REN Wei-dong
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2010, Vol. 21 
