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| The application of multi-slice spiral CT quantitative imaging technology research in COPD |
| CHEN Huai1, ZENG Qing-si1, GUAN Yu-bao1, GAO Yi1, CEN Ren-li1, ZHANG Chao-liang1, HOU Xin-ran2 |
| 1. The First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, China;2. Shenyang Neusoft Medical Systems Co., Ltd, Shenyang 110179, China |
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Abstract Objective: To correlate MSCT pulmonary function parameters and pulmonary function test parameters. To compare quantitative parameters of MSCT between COPD patients and normal volunteers, and to define the clinical feasibility parameters of MSCT in patients with COPD. Materials and Methods: Thirty cases of normal control group, forty cases of COPD with clinical pulmonary function test and MSCT scan at the end of the maximum inspiratory and maximum expiratory phase. All data was analysed by the lung analysis software of computer-aided inspection system, correlation analysis with pulmonary function parameters and comparison of the normal volunteers were made. Results: There was significant correlation with Vin/Vex and residual volume(RV)/total lung capacity(TLC)(r=0.90, P<0.01). There was significant correlation with Vin, Vex and TLC, RV(r=0.70, 0.81, respectively, P<0.01). (Vin－Vex) showed correlation with FVC(r=0.76, P<0.01). Expiratory EV-910 correlated with FEV1/FVC%(r=－0.84, P<0.01). Expiratory PI-910 had a good correlation with FEV1 and FEV1/FVC%(r=－0.86, －0.85, respectively, P<0.01). At inspiratory phase, the average Vin was (5318.15±1200.74)ml, lung density was (－898.04±35.36)HU, the density per unit volume was (0.102±0.035)g/cm3. There was no significant difference among the three parameters in normal group and COPD group(P>0.01). At expiratory phase, the average Vex was (3878.21±1202.75)ml, lung density was (－855.04±50.41)HU, the density per unit volume was (0.144±0.051)g/cm3. There was significant difference among the three parameters in normal group and COPD group(P<0.01). Conclusion: MSCT pulmonary function test can evaluate the situation and provide an objective basis for clinical diagnosis of the patients with COPD.
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Received: 04 August 2010
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Corresponding Authors:
ZENG Qing-si
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2011, Vol. 22 
