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| Value of the quantitative analysis of tissue diffusion in the grading of fatty liver |
| CHEN Yue-feng, FENG Zhan-wu, WU Li-sang, GUO Han-tao, XU Shao-lan |
| Department of Ultrasound, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China |
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Abstract Objective: To investigate the quantitative analysis of tissue diffusion by ultrasonic elastography in the grading of fatty liver. Methods: Thirty-six patients’ liver tissue samples were graded according to their level of steatosis. Before liver biopsy, the gray scale ultrasonography was performed in all patients, then, ultrasonic elastography was performed on liver tissue of ROI. The percentage of blue color in the ROI was calculated by the quantitative analysis of tissue diffusion. The elastogram was compared with level of liver steatosis. Results: Steatosis level of the thirty-six patients’ liver tissue: less than 30%(normal group) in 12 patients, 30%~50%(mild fatty liver group) in 9 patients, 50%~75%(moderate fatty liver group) in 8 patients and more than 75%(severe fatty liver group) in 7 patients. There were different characteristics in the groups’ elastogram. The difference of percentage of the blue color in ROI was statistically significant among groups. The correlation coefficient of percentage of the blue color in the ROI area and pathological stage of liver steatosis was r=0.832(P=0.000). Percentage of blue area increased with the degree of fatty liver. Conclusion: The quantitative analysis of tissue diffusion is helpful for the diagnosis in the fatty liver degree, and plays an important role in clinic.
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Received: 01 July 2011
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Corresponding Authors:
FENG Zhan-wu
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2012, Vol. 23 
