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| Comparison of TOF-PET and PSF-PET image reconstruction technique in clinical application |
| XIN Jun1, ZHAO Zhou-she2, LU Zhe2, MA Xing-rong2, QI Ru-hai2, GUO Qi-yong1 |
| 1. Shengjing Hospital of China Medical University, Shenyang 110004, China;2. General Electronic Company(China) Healthcare, Beijing 100176, China |
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Abstract Objective: TOF-PET(Time of flight-positron emission tomography, TOF-PET) and PSF-PET (Point spread function-PET, PSF-PET) were used to improve the PET performance of the latest technology. The purpose of this study was to compare TOF-PET and PSF-PET on normal tissue of brain, liver, as well as the thoracic and abdominal tumor lesions on 18F-FDG standard uptake value maximum(SUVmax) effect, so that to guide the clinical use of TOF-PET and PSF-PET technique better. Materials and methods: Thirty-five patients(male 19, female 16 cases, age 58.69±12.88 years old) with BMI 25.18±4.32 were studied. The 35 patients had 29 pulmonary lesions and 12 abdominal lesions. CT measurement of lesion diameter was in the range of 5~40 mm. GE Discovery PET/CT Elite and AW workstation was used. The SharpIR+VUE Point HD, TOF+VUE Point HD and SharpIR+VUE Point HD+TOF reconstruction method of PET images were selected. SharpIR and VUE Point HD were commercial names for PSF and iterative reconstruction respectively. Results: Compared with NO-TOF reconstruction SUVmax value of chest and abdominal lesions with TOF were increased by 7.1%(n=29, P<0.001) and 5.54%(n=12, P<0.006). In the group of BMI>25, SUVmax values of chest and abdominal lesions with TOF increased by 15.6%(n=12, P<0.001) and 20.6%(n=4, P<0.035) compared with NO-TOF. For the same group of lesions(n=6), SUVmax value by VUE HD+SharpIR, VUE HD+TOF, VUE HD+SharpIR+TOF were increased by 17.69%, 2.3%, 22.54% compared with VUE HD. For all the lesions and normal brain tissue, SUVmax values were increased by both TOF-PET and PSF-PET, but for patients with BMI greater than 25 lesions, TOF-PET raised SUVmax more obviously. Compared with TOF-PET, PSF-PET enhanced SUVmax more significantly than TOF-PET. Normal liver tissue was not affected by TOF-PET technology. Conclusion: Our results indicate that TOF-PET and PSF-PET can improve the brain lesions and normal tissue SUVmax, but PSF-PET is superior to TOF-PET. For the patients with BMI greater than 25, TOF technology increases the SUVmax value of chest and abdominal lesions more obviously.
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Received: 05 January 2012
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2012, Vol. 23 
