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| 1H-magnetic resonance spectroscopy analysis of peri-tumor region in brain glioma |
| DUAN Yang, YANG Ben-qiang, ZHOU Li-juan, MA Hong-li, LIU Wen-yuan, ZHOU Shu, LAI Shu-sheng, LIU Yu |
| Department of Radiology, Shenyang General Hospital of PLA, Shenyang 110016, China |
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Abstract Objective: To study the value of 1H magnetic resonance spectroscopy(1H-MRS) in the peri-tumor edema region of brain glioma． Materials and Methods: MRI and MRS data of 32 patients confirmed by clinical or histopathologic results were analyzed retrospectively． MRS analysis data was obtained in the medial and lateral zones of peri-tumor regions and normal brain regions. The concentration of Cho, NAA, Cr and the ratio of Cho/Cr, NAA/Cr, NAA/Cho in the lateral and medial edema regions of peri-tumor and normal brain regions were calculated． Results: NAA/Cho ratio of the normal brain regions, lateral and medial edema zones of peri-tumor was 1.67±0.64, 1.32±1.13, 0.84±0.62, respectively, there were significant difference between them(P<0.05)． The Cho concentration of the normal brain regions, lateral and medial edema zones of peri-tumor was 13.28±3.49, 15.66±8.13 and 16.38±7.77, respectively, there was no significant difference between them(P>0．05)． The NAA concentration of the normal brain regions, lateral and medial edema zones of peri-tumor was 20.67±5.52, 14.25±5.52 and 10.48±4.82, respectively, there was significant difference between them(P<0.05)． The Cr concentration of the normal brain regions, lateral and medial edema zones of peri-tumor was 11.82±3.77, 10.10±3.49 and 10.51±5.18, respectively, there was no significant difference between them(P>0.05)． Conclusion: Different metabolic changes of NAA and NAA/Cho in the peri-tumor regions can be detected by using 1H-MRS.
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Received: 09 February 2012
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2012, Vol. 23 
