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| Assessment of hepatic fibrosis stage by Gd-EOB-DTPA enhanced MR imaging: a Meta-analysis |
| ZHANG Li, LEI Jun-qiang, WANG Yin-zhong |
| Department of Radiology, the First Hospital of Lanzhou University, Lanzhou 730000, China |
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Abstract Objective: To evaluate the accuracy and quality of Gd-EOB-DTPA-enhanced MR imaging for the diagnosis of staging hepatic fibrosis. Methods: We searched the Chinese Database, Cochrane Library, Pubmed, Embase, Web of science. The retrieval times were from 2004. 1 to 2012. 12. Diagnostic tests of Gd-EOB-DTPA-enhanced MR imaging for the diagnosis of hepatic fibrosis stage were included. Data were extracted, and the quality of included studies was evaluated according to the QUADAS(Quality assessment of diagnosic accuracy studies) items. The heterogeneity test and the SROC(Summary receiver operating characteristc) curve and Meta-analysis were performed by Meta-Disc and Revman. Result: A total of 264 relevant articles were retrieved and 6 studies were included in our review involving 564 participants. Meta-analysis showed that the heterogeneities among studies were high, the pooled sensitivity and specificity of ≥F1, ≥F2, ≥F3, F4 hepatic fibrosis stages were 0.92 and 0.81, 0.76 and 0.86, 0.85 and 0.95, 0.87 and 0.92, respectively. The AUCs of SROC were 0.847 8, 0.932 2, 0.983 7 and 0.932 6, respectively. Conclusion: Gd-EOB-DTPA-enhanced MR imaging has a high value for staging hepatic fibrosis ≥F2, ≥F3, F4.
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Received: 21 January 2013
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Corresponding Authors:
LEI Jun-qiang
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2013, Vol. 24 
