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| The application of 11C-MET PET-CT in diagnosing the recurrence of cerebral glioma and in the target volume planning of three-dimensional conformal radiotherapy |
| YU Lei, WANG Ying-ying, CHE Xian-feng, SUN Ai-jun, SUN Xiao-gang |
| Wanjie Tumor Hospital of Zibo City, Zibo Shandong 255213, China |
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Abstract Objective: To study the clinical value of 11C-MET PET-CT in the diagnosis of recurrent glioma and in planning radiation therapy target. Method: 11C-MET PET-CT examination was used in 22 glioma patients with cranial MRI enhanced scan diagnosed recurrence, pathological diagnosis obtained by craniotomy and biopsy, the three-dimensional conformal radiotherapy target was sketched using the combination of PET-CT images and MR images in 12 cases with pathologically confirmed recurrence. Results: PET-CT imaging of 22 patients with 11C-MET: true positive 16 cases, true negative 5 cases, false positive 1 case and no false negative cases, the sensitivity was 95.5%(21/22), the specificity was 83.3%(5/6), the false-positive rate was 16.7%(1/6), the false-negative rate was 0, Youden index 0.788; 12 patients with histologically confirmed recurrence were given the three-dimensional conformal radiotherapy, target range of 4 cases was consistent with T1WI enhanced region, 2 cases was greater than T1WI enhanced region, four cases was less than T1WI enhanced region, the target range of 2 cases located entirely outside T1WI enhanced region. Conclusion: 11C-MET PET-CT has a high accuracy in the diagnosis of glioma recurrence, can be used in cases of MRI/CT diagnosis of recurrent, but the clinical diagnosis is not yet confirmed, and can obviously optimize radiotherapy planning in patients with glioma recurrence.
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Received: 08 November 2012
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2013, Vol. 24 
