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| Feasibility study of evaluation of liver function using Gd-EOB-DTPA-enhanced MR imaging |
| JIN La-mei1, WU Jian-wei1, QU Xian-li1, GAO Hong1, ZHANG Yan1, LU Guang-ming2 |
| 1.Department of Radiology, Bayi Clinical College of Anhui Medical University, Nanjing 210002, China;2.Department of Radiology, General Hospital of Nanjing Command PLA, Nanjing 210002, China |
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Abstract Objective: To investigate the relationship between the liver signal intensity in the hepatobiliary phase in gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid(gadoxetic acid, Gd-EOB-DTPA)-enhanced magnetic resonance imaging and liver function. Methods: This study included 55 patients with cirrosis due to hepatitis B and 18 adult normal as control group, the subjects received laboratory tests of liver function to perform the Child-Pugh score and MR imaging before injection and at 5, 10, 15, 20 and 25 minutes after bolus administration of Gd-EOB-DTPA, the signal intensities of liver and spleen at each time point were measured. The differences of the absolute value of liver, DSI(the differences of liver signal intensity between the hepatobiliary phase and plain scan), liver-to-spleen contrast ratio were analysed. The relationships between the signal intensity and total bilirubin level, albumin level, and prothrombin time were also evaluated. Results: According to the Child-Pugh score, there were 35 patients in Child-Pugh A group, 18 in B group and 2 in C group. The signal intensity, DSI, and liver-to-spleen contrast ratio showed significant differences among the control group, Child-Pugh A group and Child-Pugh B group at each time point. There were no differences of the liver signal intensity at 15, 20 and 25 minutes in 55 patients(F=0.121, P=0.886). Liver signal intensity in hepatobiliary phase positively correlated with and serum albumin level and negtively correlated with the total bilirubin level, prothrombin time. Conclusion: The degree of liver enhancement in hepatobiliary phase may be used to estimated liver function and correlate with the serum albumin level, total bilirubin level, prothrombin time. The delay time of 15 minutes was suitable for liver functional assessment.
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Received: 21 March 2013
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2013, Vol. 24 
