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| Flow mediated dilation of brachial artery and popliteal artery in diabetic kidney disease using high frequency ultrasound: a comparative study |
| ZHANG Yue-yue, XU Yan, LI Xiang |
| The Affiliated Hospital of Qingdao University, Qingdao Shandong 266003, China |
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Abstract Objective: To study the difference of vascular endothelial function by evaluating flow mediated dilation(FMD) of brachial artery and popliteal artery in diabetic kidney disease(DKD) patients with high frequency ultrasound. Methods: Vascular diameter and velocity in baseline and after reactive hyperaemia of brachial artery and popliteal artery were detected with high frequency ultrasound in 20 healthy volunteers, type 2 diabetic mellitus(T2DM) and patients with DKD-V pre-hemodialysis, FMD were calculated and compared between the 3 groups. Results: Difference of brachial artery FMD and popliteal artery FMD between each two groups were significant(P<0.05). Difference of FMD between brachial artery and popliteal artery in each group were significant(P<0.05). The difference between each two groups of brachial artery and popliteal artery FMD were significant(P<0.05) and increased as disease progress. Conclusion: When T2DM involved kidney, endothelial dysfunction of popliteal artery progress faster than brachial artery.
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Received: 05 August 2013
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Corresponding Authors:
XU Yan
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2014, Vol. 25 
