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| Transrectal real-time elastography in the differential diagnosis of prostate cancer in patients with raised PSA level |
| ZHAN Jia, ZHU Jun, CHAI Qi-liang, WANG Dong-ya, CHEN Yue |
| Department of Ultrasound, Huadong Hospital of Fudan University, Shanghai 200040, China |
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Abstract Objective: To evaluate the value of real-time elastography(RTE) in the differential diagnosis of prostate cancer(PCa). Methods: Patients with raised PSA level suspected of PCa underwent transrectal ultrasound(TRUS) and RTE examinations. Based on the TRUS and PSA level, the patients were divided into two groups: group 1: PSA≥10.0 ng/mL, without nodular lesion in the peripheral zone, group 2: PSA≥4.0 ng/mL, with nodular lesion in the peripheral zone. RTE were classified into 5 elastography scoring(ES)，comparing with the results of prostate biopsy pathological findings. ROC curves were drawn to evaluate their differential diagnostic results in the two groups. Result: High quality images of RTE were obtained in 90 patients of 105 cases. According to the pathological results, the areas under the ROC curve were 0.58 and 0.83 respectively. Taking ES≥4 as the cutoff, there were significant differences in accuracy and negative predictive value(P<0.05) between the two groups. Conclusion: RTE is helpful to the differential diagnosis of prostate cancer, especially those with peripheral zone lesions.
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Received: 16 December 2013
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Corresponding Authors:
CHEN Yue
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2014, Vol. 25 
