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| Correlation between intratumoral flow assessed by color Doppler and microvascular density, together with expression of Ang-2 in ovarian tumor |
| WANG Juan-juan, YU Bing |
| Department of Obstetrics and Gynecology, Shanxi Academy of Medical Sciences, Shanxi Dayi Hospital, Taiyuan 030032, China |
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Abstract Objective: To evaluate the correlation between intratumoral blood flow index of resistance index(RI), assessed by color Doppler and microvascular density(MVD), together with expression of angiopoietin-2(Ang-2) in ovarian tumor. Methods: For 55 patients with ovarian tumor proved by pathologic histology examination, CDFI was performed preoperatively to detect the arterial blood flow signals, and the lowest RI values were recorded. MVD and the expression of Ang-2 were examined by immunohistochemical assay. Results: There was a significant negative correlation with RI for benign and malignant ovarian tumors(r=－0.577, P＜0.05). With the increase of tumor grade, MVD showed a significantly positive correlation(r=0.750, P＜0.01). There was a negative correlation between RI value and MVD(r=－0.537, P＜0.05). Ang-2 and tumor grade were significantly positively correlated(r=0.573, P＜0.05). Conclusions: Ang-2 is expected to be one of the indicators of clinical diagnosis of ovarian cancer. Combined application of RI, MVD and Ang-2 can comprehensively evaluate the angiogenesis of ovarian tumors before and after operation, which could be helpful in forecasting prognosis and therapy of ovarian cancer.
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Received: 30 March 2015
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Corresponding Authors:
YU Bing
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2015, Vol. 26 
