MR扩散峰度成像在鉴别高级别胶质瘤与转移瘤中的价值

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Abstract Abstract: Objective: To investigate the value of magnetic resonance diffusion kurtosis imaging(DKI) in differential diagnosis of intracerebral primary high-grade gliomas and single intracerebral metastasis tumor through multiple parameters including MK value, MD value and FA value. Methods: Thirteen cases of high-grade gliomas and 12 cases of single intracerebral metastasis tumors confirmed by pathology were collected from January 2013 to May 2015. All patients underwent conventional MRI sequences and DKI sequence. Region of interest was located at both the solid area and the surrounding edema zone of the tumors respectively, and MK, MD, FA values were measured. Standardized corrections were performed for contralateral normal brain white matter. Then corresponding standard parameters of MK’, MD’, and FA’ values were obtained. Independent samples t test was performed to compare DKI parameters of both solid area and edema region for high grade gliomas and metastasis tumors. Results: MK, MD and FA values in the solid area and surrounding region of high grade glioma tumor were 0.84±0.21, (1.28±.30)×10-3 mm2/s, 0.26±0.17; 1.19±0.26, (1.07±0.22)×10-3 mm2/s, 0.28±0.12 respectively. The DKI values of above-mentioned regions of intracranial atypical metastases were 0.80±0.20, (1.48±0.45)×10-3 mm2/s, 0.17±0.12; 0.86±0.18, (1.54±0.46)×10-3 mm2/s, 0.22±0.14 respectively. There was no statistical difference for DKI parameters of the solid region between gliomas and metastasis. There was significant difference for MK and MD values of the surrounding region between gliomas and metastasis(P<0.05), however there was no significant difference for the FA value. After the correction, there was significant difference for the MK’, MD’ values of surrounding region between two kinds of tumors(P<0.01), and there was no statistical difference for other corrected parameters. Conclusion: The MK and MD values of surrounding edema region have important value in differential diagnosis of high-grade gliomas and cerebral metastasis.

Key words： Glima Brain neoplasms Magnetic resonance imaging

Received: 09 June 2015

PACS:	Ｒ739.41
	Ｒ730.264
	Ｒ445.2

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	LIU Pei-zheng
	SHEN Xiao-jun
	LI Jun
	GENG Jun-zu

Cite this article:

LIU Pei-zheng,SHEN Xiao-jun,LI Jun, et al. The value of magnetic resonance diffusion kurtosis imaging in differential diagnosis of high grade gliomas and metastatic tumor[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2015, 26(12): 841-843.

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http://www.jccmi.com.cn/EN/ OR http://www.jccmi.com.cn/EN/Y2015/V26/I12/841

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