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| A comparative study of HRCT findings and pathological basis of intralobular lines in coal workers’ pneumoconiosis |
1. Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China;
2. Beijing Fengtai Hospital, Beijing 100071, China;
3. National Research Center for Occupational Safety and Health, Beijing 102300, China |
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Abstract Objective: To evaluate the imaging features of high-resolution CT(HRCT) and pathological basis in patients with coal workers’ pneumoconiosis(CWP). Methods: Fifty-two fresh lungs from patients with CWP were fixed and inflated by the Heitzman method. The inflated specimens underwent HRCT coronal and transverse planes scanning. Two experienced chest radiologists independently made the diagnosis results. The evaluation parameters included intralobular lines, micronodules, ground-glass opacity(GGO), thickened intralobular septa, crazy-paving pattern, bronchiectasis, and honeycombing. A comparative study of image and pathology was performed on the tissue sections according to the HRCT region of interest. Results: Of the 52 specimens, 21 were excluded because of structure distortion, and 31 were enrolled in this study. In the transverse projection, only 16.1% of the specimens exhibited peribronchovascular predominance, and 38.7% exhibited subpleural predominance. In the coronal view, the incidence of distribution in the upper-zone was only 16.1%. Among the accompanying signs of intralobular lines, micronodules and thickened interlobular septa were the most common observations(100%), followed by GGO(83.9%) and emphysema(80.6%). The intralobular lines on HRCT corresponded to thickened alveolar septa that were associated with coal macules, fibrosis, inflammation, tumors, and serous fluid based on pathology. Conclusion: The intralobular lines of CWP on HRCT correlate with a variety of pathological backgrounds. The thickened interlobular septa are the most frequent accompanying sign.
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Received: 11 May 2015
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[1]Webb WR, Müller NL, Naidich DP. High resolution CT of the lung[M]. 3rd ed. Philadelphia: Lippincott Williams & Wilkins, 2000: 49-59.
[2]Hansell DM, Bankier AA, MacMahon H, et al. Fleischner Society: glossary of terms for thoracic imaging [J]. Radiology, 2008, 246(3): 697-722.
[3]Corn M, Stein F, Hammad Y, et al. Physical and chemical characteristics of “respirable” coal mine dust [J]. Ann N Y Acad Sci, 1972, 200: 17-30.
[4]Wang ZG, Ma DQ, Chen BD, et al. Morphologic manifestation of interlobular septa and pathologic basis in different stage coal worker’s pneumoconiosis on high-resolution CT[J]. Chin J Radiol, 2006, 40(7): 718-721.
[5]Rom WN. Basic mechanisms leading to focal emphysema in coal workers’ pneumoconiosis[J]. Environ Res, 1990, 53(1): 16-28.
[6]Akkoca Yildiz O, Eris Gulbay B, Saryal S, et al. Evaluation of the relationship between radiological abnormalities and both pulmonary function and pulmonary hypertension in coal workers’ pneumoconiosis[J]. Respirology, 2007, 12(3): 420-426.
[7]Chong S, Lee KS, Chung MJ, et al. Pneumoconiosis: comparison of imaging and pathologic findings[J]. Radiographics, 2006, 26(1): 59-77.
[8]Sozio F, Rossi A, Weber E, et al. Morphometric analysis of intralobular, interlobular and pleural lymphatics in normal human lung[J]. J Anat, 2012, 220(4): 396-404.
[9]Sumikawa H, Johkoh T, Fujimoto K, et al. Pathologically proved nonspecific interstitial pneumonia: CT pattern analysis as compared with usual interstitial pneumonia CT pattern[J]. Radiology, 2014, 272(2): 549-556.
[10]Jeong YJ, Lee KS, Chung MP, et al. Chronic hypersensitivity pneumonitis and pulmonary sarcoidosis: differentiation from usual interstitial pneumonia using high-resolution computed tomography[J]. Semin Ultrasound CT MR, 2014, 35(1): 47-58.
[11]Bertolotti A, Defranchi S, Vigliano C, et al. Surgical lung biopsy in transplant patients with diffuse lung disease: how much worse when the lung is the graft?[J]. Ann Thorac Surg, 2013, 96(1): 279-285.
[12]Wang Q, Zhang Z, Shi Y, et al. Emerging H7N9 influenza A(novel reassortant avian-origin) pneumonia: radiologic findings[J]. Radiology, 2013, 268(3): 882-889.
[13]Dai J, Zhou X, Dong D, et al. Human infection with a novel avian-origin influenza A(H7N9) virus: serial chest radiographic and CT findings[J]. Chin Med J(Engl), 2014, 127(12): 2206-2211.
[14]Jin GY, Lynch D, Chawla A, et al. Interstitial lung abnormalities in a CT lung cancer screening population: prevalence and progression rate[J]. Radiology, 2013, 268(2): 563-571.
[15]Heitzman ER. The lung: radiologic-pathologic correlations[M]. 2nd ed. St Louis: Mosby, 1984: 4-12.
[16]Churg A, Green FH. Pathology of occupational lung disease[M]. New York-Tokyo: Igaku-Shoin, 1988: 213-234.
[17]McLoud TC, Boiselle PM. Thoracic Radiology: The Requisites[M]. 2nd ed. St Louis: Mosby, 2010: 145-301. |
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