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| The relationship between primary lesion glucose metabolism of NSCLC andchemotherapy: a preliminary study according to PERCIST criteria |
| CHEN Mei-jie, LI Na, DU Bu-lin, LI Ya-ming |
| Nuclear Medicine Department, the First Hospital of China Medical University, Shenyang 110001, China |
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Abstract Objective: The aim of this study was to investigate whether metabolic tumor volume(MTV) and total lesion glycolysis(TLG) of primary tumor could give a prediction of the sensitivity in non-small cell lung cancer chemotherapy. Method: Eighteen cases with phase Ⅲ~Ⅳ non-small cell lung cancer patients were reviewed retrospectively, who received platinum-based first-line chemotherapy and had 18F-FDG PET/CT examinations both before and after therapy. MTV and TLG were determined with two thresholds which were 30% SUVmax and 50% SUVmax, using PERCIST criteria to evaluate outcome. Statistical analysis included rank-sum test and ROC curve. Results: The change rates of indicators including ΔTLG30% SUVmax(u=73, P=0.003), ΔMTV30% SUVmax(u=73, P=0.003), ΔTLG50% SUVmax(u=65, P=0.025), ΔMTV50% SUVmax(u=65, P=0.025) and ΔSUVmax(u=74, P=0.003) were statistically significant. According to ROC curve, change rates of TLG and MTV were 62.2% and 56.3% respectively could discriminate sensitivity to chemotherapy with threshold of 30% SUVmax, as well as 68.9% and 63.3% with threshold of 50% SUVmax. Conclusions: The change rates of TLG and MTV of primary tumor in non-small cell lung cancer patients can contribute to filtering out chemotherapy sensitivity.
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Received: 12 August 2014
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Corresponding Authors:
LI Ya-ming
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2015, Vol. 26 
