DCE-MRI in differential diagnosis of liver lesions
Yusufu·Rouzi1, WANG Yun-ling1, WANG Hong1, NIE Cong-ke1, Arkin·Abliz2, MA Jing-xu1, JIANG Tao1, JIA Wen-xiao1
1. Department of Imaging Center, the Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830063, China;2. Department of Imaging Center, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
Abstract Objective: To evaluate the value of quantitative parameters of DCE-MRI in the diagnosis of liver lesions． Methods: Fifty-five patients of liver tumors underwent MRI examination. MR scanner was used to obtain the quantitative MR pharmacokinetic parameters: Ktrans(volume transfer constant), Kep(exchange rate constant) and Ve(extravascular extracellular volume fraction)． The mean Ktrans, Kep and Ve of liver cancer, liver hemangioma and liver metastasis were calculated and compared with each other using LSD method. Receiver operating characteristic curve(ROC) analysis was used for comparing the difference between liver cancer and liver hemangioma． Results: There were significant differences in Ktrans and Ve(P<0．05) between liver cancer and liver hemangioma, liver hemangioma and liver metastasis, liver cancer and liver metastasis, and also in Kep(P<0．05) between liver hemangioma and liver cancer, liver cancer and liver metastasis. There was no significant difference between liver hemangioma and liver metastasis in Kep(P>0．05). The sensitivity of Ktrans, Ve, and Kep were 88.2％, 82.4％ and 94.1％ respectively, and the specificity of Ktrans, Ve and Kep were 81.8％, 59.1％ and 81.8％ respectively for the differential diagnosis of liver cancer and liver hemangioma. The sensitivity of Ktrans, Ve and Kep were 68.2％, 68.2％ and 50.0％ respectively, and the specificity of Ktrans, Ve and Kep were 81.2％, 87.5％ and 81.2％ respectively for the differential diagnosis of liver hemangioma and liver metastasis. The sensitivity of Ktrans, Ve and Kep were 100.0％, 82.4％ and 100.0％ respectively, and the specificity of Ktrans, Ve, and Kep were 93.7％, 93.7％ and 93.7％ respectively for the differential diagnosis of liver hemangioma and liver metastasis, with the maximum Youden’s index as cut-off． Conclusion: The differential diagnosis of liver lesions by Ktrans, Kep derived from DCE-MRI is valuable．
2015, Vol. 26 
