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| A Meta-analysis of magnetic resonance elastography for the staging of hepatic fibrosis |
| WANG Wei, WEN Feng, ZHAO Xiang-xuan, SHI Yu, WANG Yue-ren, GUO Qi-yong |
| Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110004, China |
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Abstract Objective: A Meta-analysis was performed to investigate the diagnostic value of Magnetic Resonance Elastography(MRE) for different stages of hepatic fibrosis. Methods: English articles related to MRE diagnosis for hepatic fibrosis from various data resources including PUBMED, EMBASE, Web of Science, and Cochrane Library database were collected and evaluated. Using a checklist based on the Quality Assessment for Studies of Diagnostic Accuracy-2(QUADAS-2), the methodological quality of each study was characterized. Stata 12.0 software was used to synthetically analyze the experimental data from different English literatures. Results: 18 studies were finally collected which met all inclusion criteia. The pooled sensitivity and specificity for F≥1, F≥2, F≥3, and F=4 were 0.87, 0.9, 0.94, 0.98 and 0.95, 0.94, 0.91, 0.94, and the areas under curve(AUC) were 0.97, 0.97, 0.96, and 0.98, respectively. Conclusion: MRE has a higher diagnostic value for determining different hepatic fibrosis stages.
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Received: 19 November 2014
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2015, Vol. 26 
