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| Discussion on method selection of region of interest during prostate dynamic contrast-enhanced MR imaging |
| GAO Jin1, ZHOU Han1, OUYANG Yu1, LIU Hong1, DAI Mao-liang1, WU Xiao-yun2 |
| 1.Department of Radiology, the Second Affiliated Clinical College of Chengdu of Chongqing Medical University andthe Third People’s Hospital of Chengdu, Chengdu 610031, China; 2.Department of Radiology,Sichuan Provincial People’s Hospital, Chengdu 610072, China |
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Abstract Objective: To discuss the influence of different regions of interest(ROI) on the time-intensity curve(TIC) and its value during dynamic contrast-enhanced MRI(DCE-MRI). Method: Prostate DCE-MRI was performed on all the 99 patients. There were 118 lesions in the peripheral zone, including 55 benign lesions and 63 prostate cancers. On dynamic contrast-enhanced MRI, the TIC of a large ROI(20~150 mm2) on the central layers of the foci and 13 small ROIs(6.6 mm2) scattering inside the foci were obtained. The difference between the TICs of the large and small ROIs in the benign and malignant prostate foci was compared. Two protocols were adopted to classify the TIC of the foci, and then PI-RADS score to DCE-MRI was carried out respectively. Protocol 1: The type of curve was big ROI curve. Protocol 2: The type of curve was type 3 curve if there was such a curve in any small ROI. Otherwise, it was regarded as a large ROI curve. Result: The median number of small ROIs with the type of big ROI curve in the foci was 12 for the benign lesions and 10 for the prostate cancer. The median test result was P=0.003. For diagnosis of prostate cancer, the sensibility and specificity of Protocol 1 were 76.36% and 90.48%, while the sensibility and specificity of Protocol 2 were 87.27% and 85.71%(P=0.031 and P=0.250 respectively). Conclusion: Enhancement at different ROIs of the foci of prostate cancer did not go all the same way. It is helpful for the diagnosis of prostate cancer in the peripheral zone to adopt small ROIs to seek type 3 curve.
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Received: 31 October 2014
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2015, Vol. 26 
