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| The pilot research of assessing the efficacy of telbivudin anti-fibrosis treatment in chronic hepatitis B by real-time shear wave elastography |
| SHI Hong-mei, WANG Qian-hui, GAO Li |
| Taiyuan No.3 Hospital, Taiyuan 030012, China |
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Abstract Objective: To assess the effect of telbivudin anti-fibrosis treatment in chronic hepatitis B by using the liver Young’s modulus of patients with chronic hepatitis B tested by real-time shear wave elastography. Methods: Eighty chronic hepatitis B patients with liver fibration(liver biopsies were performed before treatment) were enrolled and divided into 3 groups, group A(S0, S1) which contains 22 patients, group B(S2, S3) which contains 40 patients, and group C(S4) which contains 18 patients. All the patients were under the treatment of telbivudin, and respectively tested the liver Young’s modulus before treatment and 24 weeks after treatment by using real-time shear wave elastography, and the serum test including hyaluronic acid(HA), laminin(LN), type Ⅳ collagen(CL-Ⅳ), serum type Ⅲ procollagen(PⅢPN-P) were measured in all patients. Result: All serum index(HA, LN, CL-Ⅳ and PⅢPN-P) in three groups decrease 24 weeks after treatment vs before, the difference is statistically significant(P＜0.05), and Young’s modulus of liver tested by real-time shear wave elastography also decrease 24 weeks after treatment vs before, the difference is statistically significant(P＜0.05), Young’s modulus of liver in three groups were group A＜group B＜group C 24 weeks after treatment and before. Conclusion: Real-time shear wave elastography testing liver flexible modulus could be used in assessing the effect of telbivudin treatment in chronic hepatitis B.
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Received: 29 December 2014
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2015, Vol. 26 
