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| Contrast-enhanced ultrasonic discrepancy of different lesion size, pathological type and histological grading in breast cancer |
| LENG Xiao-ling1, HUANG Guo-fu2, MA Fu-cheng1 |
| 1. Department of Ultrasonography, the Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi 830011, China;2. Department of Radio-chemotherapy, the Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China |
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Abstract Objective: To explore the differences of enhanced ultrasound features of the different lesion size, pathological type and histological grading of breast cancer. Methods: Contrast-enhanced ultrasound perfusion modes were analyzed retrospectively in 113 cases of breast cancer patients with 119 lesions. The ultrasonic contrast enhancement characteristics, including enhanced range, enhanced strength, contrast agent distribution, entering sequence, contrast mode, the perforator vessel and perfusion defects etc. were also analyzed. Postoperative pathological types and size, histological grade in breast cancer tissue were collected. To analyze the relationship between contrast-enhanced ultrasonography and lesion size, pathological type, histological grading. Results: Lesions less than 2 cm were more inclined to mild enhancement or moderate enhancement, without blood flow perfusion defect and without perforator; breast cancer lesions more than 2 cm were more inclined to marked enhancement, the existence of perfusion defects and perforator(P<0.05). But whether the range of lesions detected by contrast enhanced ultrasound range is greater than the two-dimensional ultrasound or not, contrast agent distribution characteristics, entry order of contrast agent, imaging sequence model differences were unrelated to lesion size(P>0.05). After contrast enhancement, the ratio of peripheral enhancement, high strength reinforced, peripheral enhancement, speed up and slow down in breast cancer lesions with histological grade Ⅲ level was higher than that of histological grade Ⅰ or Ⅱ tumor(P<0．05). There were no differences in enhanced range, contrast agent entry order, perfusion defects and perforator vessel between the different histological grade of breast cancer(P>0.05). Conclusion: Effect of lesion size and histological grading on contrast enhanced ultrasound features was stronger than the tumor pathological type. Contrast enhanced ultrasound of breast cancer may play a certain role of histological grading.
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Received: 22 December 2014
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Corresponding Authors:
MA Fu-cheng
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2015, Vol. 26 
