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| Value of dual source CT dual energy imaging in determining the serosa invasion of colon cancer |
| CHEN Ji-hu1, WU Zhi-feng2, E Lin-ning2, WU Shan2, WANG Rong-hua2 |
| 1. Shanxi Medical University, Taiyuan 030001, China; 2. CT Room, Shanxi Dayi Hospital, Taiyuan 030032, China |
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Abstract Objective: To explore the value of measuring iodine concentration(IC) in perienteric adipose tissue with dual source CT dual energy imaging for detection of serosa invasion of colon cancer． Methods: Forty-five patients with colon cancer confirmed by surgery and pathology from April to October 2015 were analyzed retrospectively, and all patients underwent preoperative dual energy imaging． IC of perienteric adipose tissue was measured in serosa invasion group(n=14) and uninvaded group(n=31) at arterial phase(AP) and venous phase(VP), respectively． Two independent samples nonparametric Mann-Whitney U test was used for statistical analysis and ROC curve was used to evaluate the value of IC in determining serosa invasion． Results: IC of perienteric adipose tissue was significantly higher in serosa invasion group than that in uninvaded group (AP: 0.55 mg/mL vs 0.03 mg/mL, Z=－4.72, P＜0.001; VP: 0.48 mg/ml vs 0.10 mg/ml, Z=－3.68, P＜0.001)． With a cut-off of 0.29 mg/mL at AP, area under curve(AUC) was 0.93, the sensitivity and specificity for determining serosa invasion were 92.9％ and 93.5％, respectively． With a cut-off of 0.42 mg/mL at VP, AUC was 0.84, the sensitivity and specificity were 85.7％ and 80.6％, respectively． Conclusion: Measuring IC in perienteric adipose tissue with dual energy imaging has a more accurate judgment of serosa invasion in patients with colon cancer than only by CT signs．
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Received: 14 February 2016
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