11C-胆碱PET/CT显像在前列腺癌诊断中对18F-FDG的补充价值

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Abstract Objective: To analyse the added value of 11C-choline PET/CT imaging to 18F-FDG PET/CT in primary prostate cancer. Methods: A prospective study of 18F-FDG PET/CT and 11C-choline PET/CT imaging in prostate patients encountered in our hospital from Oct 2011 to Jan 2016, a total of 63 male patients were included in the study. Including 38 cases of prostate cancer(mean age: 71 years old), 25 cases of benign prostatic hyperplasia(mean age: 66.5 years old), all cases were diagnosed by histopathology or follow-up or more for the standard diagnosis. Comparing 11C-choline with 18F-FDG PET/CT imaging for further analysis of the added value of 11C-choline PET/CT imaging to a 18F-FDG PET/CT in primary prostate cancer patients. Results: The 11C-choline PET/CT imaging showed that the SUVmax of the prostate cancer group(3.91±3.29) higher than the benign prostatic hyperplasia(1.01±1.10). The SUVmax of 18F-FDG was no stastistical difference with the prostate cancer(3.98±4.17) and the benign prostatic hyperplasia(2.17±3.33). The sensitivity, the specificity, the accuracy, the positive predictive value and the negative predictive value of 11C-choline PET/CT and 18F-FDG PET/CT are 89.5%, 81.6%, 88.0%, 60.0%, 88.9%, 73.0%, 91.9%, 75.6%, 84.6%, 68.2%, respectively. The sensitivity, the specificity, the accuracy, the positive predictive value and the negative predictive value of combined two radioactive tracers scan is 89.5%, 96%, 92.1%, 97.1%, 85.7%, respectively. Seventeen cases of bone metastases, 8 cases of lymph node metastasis, 1 case of pulmonary metastasis were recognized by PET/CT. The SUVmax of bone metastasis of 11C-choline PET/CT has no obviously variance compared with 18F-FDG PET/CT. 11C-choline PET/CT imaging showed that bone metastases lesions(584) were more than 18F-FDG PET/CT(497), that difference was statistically significant(t=2.151, P<0.05). The SUVmax of lymph node metastasis and total number is no statistical difference between 11C-choline PET/CT imaging and 18F-FDG PET/CT(P>0.05). Conclusions: 11C-choline PET/CT imaging combined with 18F-FDG PET/CT imaging has better diagnostic value in the prostate cancer. 11C-choline PET/CT can make up for the inadequacy of 18F-FDG PET/CT.

Key words： Prostatic neoplasms Fluorodeoxyglucose F18 Positron-emission tomography

Received: 20 May 2016

PACS:	Ｒ737.25
	Ｒ817.4

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	Articles by authors
	NA Ren-hua
	CHAI Li-ming
	JURETI Azhati
	CAO Wu-cheng
	LI Ming
	YANG Xiao-feng

Cite this article:

NA Ren-hua,CHAI Li-ming,JURETI Azhati, et al. Added value of 11C-choline PET/CT imaging to 18F-FDG PET/CT in primary prostate cancer[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2016, 27(11): 799-803.

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http://www.jccmi.com.cn/EN/ OR http://www.jccmi.com.cn/EN/Y2016/V27/I11/799

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