|
|
|
| Diagnostic value of color ultrasonography with serum CA125 and CA724#br#
in the differential diagnosis of benign and malignant ovarian tumor |
1. The People’s Hospital of Hainan Province, Haikou 570311, China;
2. School of Public Health, Sun Yat-sen University, Guangzhou 510080, China |
|
|
|
|
Abstract Objective: To explore the diagnostic value of color ultrasonography with serum CA125, CA724 in the benign and malignant ovarian tumor. Method: One hundred and six patients with ovarian tumors who had operation from January to October 2015 in our hospital were detected with color ultrasound and serum CA125 and CA724 levels. Result: The CA125 and CA724 levels of 23 cases with ovarian malignant tumor were higher than that of the 83 patients with benign tumors(P<0.05). The coincidence rate of ultrasound diagnosis was 56.5%. The positive rate of ovarian cancer with combined detections of all three indicators was 78.3% in malignant group, significantly higher than 37.3% of benign group(P<0.05). The sensitivity, specificity, accuracy and the positive predictive value in the diagnosis of ovarian cancer is relatively higher by the detection of color ultrasound combined with CA125, even higher than the joint diagnosis of the three indicators above. Conclusion: Color ultrasonography detection with serum tumor markers can partly improve the differential diagnosis of ovarian benign and malignant tumors.
|
|
|
|
|
|
|
|
[1]Jemal A, Siegel R, Ward E, et al. Cancer statistics 2009[J]. CA Cancer J Clin, 2009, 5(59): 25-249.
[2]孙巍，王琼，刘娟. 血清肿瘤标志在结直肠癌诊断中的应用[J]. 中华检验医学杂志，2000，23（1）：13.
[3]杨琦，袁媛，孙伟莉，等. CA125、CA724联合检测在卵巢癌诊断中的应用[J]. 皖南医学学报，2010，29（4）：284-285.
[4]李宜川，芦琨，赵炎. 联合检测血清CA125、CA199、CA153和CA724对卵巢癌的诊断价值[J]. 中国妇幼保健，2012，27（2）：271-273.
[5]李丽，吴青青，谢玉娴． 应用超声鉴别卵巢肿瘤良恶性的研究进展[J]． 临床超声医学杂志，2006，8（6）：63-365．
[6]罗玲，欧阳颖，罗晓红. 血清CA125、CA153、CA724联合检测对卵巢恶性肿瘤的诊断价值[J]. 中国实用医药，2012，7（32）：42-43.
[7]夏俊. 卵巢癌血清学标志物联合检测模式探讨[J]. 中国妇幼保健，2012，32（27）：5157-5158.
[8]Shah CA, Lowe KA, Paley P. Influence of ovarian cancer risk status on the diagnostic performance of the serum biomarkers mesothelin, HE4 and CA125[J]. Cancer Epidemiol Biomarkers Prev, 2009, 18(5): 1365-1372.
[9]高玉香，刘诚明. 血清肿瘤标志CA125、CA724在卵巢癌诊断中的应用[J]. 中国妇幼保健，2009，20（24）：2881-2882.
[10]黄飞雪，白华，杨水华，等. 超声诊断卵巢肿瘤良恶性的进展[J]. 广西医学，2014，36（12）：1775-1777.
[11]刘志慧，顾振鹏. 卵巢癌早期诊断的研究进展[J]. 滨州医学院学报，2010，33（4）：285.
[12]Bast RC, Brewer M, Zou C, et al. Prevention and early detection of ovarian cancer: mission impossible?[J]. Recent Results Cancer Res, 2007, 174: 91-100. |
|
|
|
