多烯紫杉醇联合碘化油介入方案治疗肝脏恶性肿瘤的临床应用研究

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Abstract Objective: To explore the clinical effect of intervention programme using docetaxel combined with iodized oil in the treatment of liver cancer. Methods: Forty-three cases of primary advanced liver cancer were randomly divided into group A(docetaxel group with 22 cases) and group B (conventional therapy group with 21 cases). The patients in group A received injection of dexamethasone 10 mg to prevent allergic reaction firstly, and then docetaxel 60 mg/m2 dissolved in 100 mL of 0.9% saline was infused slowly. And finally transarterial embolism was performed with slow injection of 5-FU 250 mg and 5~20 mL iodine suspension until iodine oil deposited in the tumor foci was thick or blood flow slowed down. Patients in group B were treated with different combination of epirubicin(EADM) 40~60 mg/m2, mitomycin(MMC) 8 mg/m2, cisplatin(DDP) 60 mg/m2 or hydroxy camptothecin(HCPT) 20 mg/m2 according to the patients’ conditions, together with iodine oil. Then the short-term efficacy, the patient’s survival and the complications after treatment were compared. Results: The 6 and 12 months survival rates were 94.5%, 48.9% and 91.6%, 37.6% respectively for group A and group B, and the survival rates of the two groups were significantly different(P<0.05), while the complications in the two groups were not significantly different. Conclusion: Docetaxel-containing regimen can improve the life quality of patients with primary liver cancer compared with conventional chemotherapy treatment, and can prolong the survival of patients to a certain extent.

Key words： Liver noeplasms Iodized oil Embolization, therapeutic Tomography, spiral computed

Received: 02 December 2015

PACS:	Ｒ735.7
	R815
	Ｒ814.42

Corresponding Authors: WANG Jia-ping

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	KONG Peng1
	MENG Ling-ping1
	YANG Bin1
	WANG Jia-ping2

Cite this article:

KONG Peng1,MENG Ling-ping1,YANG Bin1, et al. Clinical research of docetaxel combined with iodized oil for the treatment of liver tumor[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2016, 27(7): 482-486.

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http://www.jccmi.com.cn/EN/ OR http://www.jccmi.com.cn/EN/Y2016/V27/I7/482

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