脑肿瘤患者术前语义、语法任务相关的脑语言功能磁共振成像研究

Abstract
Figure/Table
References (0)
Related Citation (15)

Download: PDF (0 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To observe the location and the language lateralization of language functional areas in patients with brain tumors. To evaluate the relationship between the location of the lesion and the language lateralization of functional language areas, and determine the Chinese language hemisphere. Finally analyzed the cause of this phenomenon. Methods: Nineteen patients were enrolled the study, to perform the semantic and syntactic paradigm. Functional data was collected when performed the language tasks and analyzed by SPM8. Using specify 2nd level(single sample t-test) for group analysis. Then locating the functional language areas and determining the Chinese language hemisphere. Results: In the case of 19 patients with brain tumors, bilateral medial frontal gyrus, bilateral superior frontal gyrus, right medial frontal gyrus, bilateral superior temporal gyrus, left inferior temporal gyrus, left middle temporal gyrus, the bilateral supramarginal gyrus etc were significantly activated. The LI was more than 0. The dominant hemisphere in patients with brain tumor was in left side. Conclusion: The mass effect due to growth of the brain tumors led to the restructuring of the brain tissue. And the normal brain regions around the lesion and the right hemisphere corresponding mirror brain areas may compensate for the part of the language function. BOLD-fMRI provides a reliable method for evaluating the relationship between the location of the lesion and the functional language areas. It is helpful for perfectly excision of the lesion in the surgery.

Key words： Brain neoplasms Magnetic resonance imaging

Received: 21 October 2015

PACS:	Ｒ739.41
	Ｒ445.2

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LIU Yong-jian1
	HUANG Biao2
	ZHOU Shou-guo1
	FENG Yan-yun3
	LIANG Chang-hong2
	ZHANG Jia-xiong1

Cite this article:

LIU Yong-jian1,HUANG Biao2,ZHOU Shou-guo1, et al. Functional MRI study of the functional language area with brain tumor preoperatively related with the semantic and syntactic paradigm[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2016, 27(8): 533-537.

URL:

http://www.jccmi.com.cn/EN/ OR http://www.jccmi.com.cn/EN/Y2016/V27/I8/533

[1]Schramm J, Aliashkevich AF. Surgery for temporal mediobasal tumors: experience based on a series of 235 patients[J]. Neurosurgery, 2008, 62(6 Suppl 3): 1272-1282.
[2]Ruff IM, Petrovich Brennan NM, Peck KK, et al. Assessment of the language laterality index in patients with brain tumor using functional MR imaging: effects of thresholding, task selection, and prior surgery[J]. AJNR, 2008, 29(3): 528-535.
[3]Giussani C, Roux FE, Ojemann J, et al. Is preoperative functional magnetic resonance imaging reliable for language areas mapping in brain tumor surgery? Review of language functional magnetic resonance imaging and direct cortical stimulation correlation studies[J]. Neurosurgery, 2010, 66(1): 113-120.
[4]Stippich C, Rapps N, Dreyhaupt J, et al. Localizing and lateralizing language in patients with brain tumors: feasibility of routine preoperative functional MR imaging in 81 consecutive patients[J]. Radiology, 2007, 243(3): 828-836.
[5]Gartus A, Foki T, Geissler A, et al. Improvement of clinical language localization with an overt semantic and syntactic language functional MR imaging paradigm[J]. AJNR, 2009, 30(10): 1977-1985.
[6]冯燕韻，黄飚，高明勇，等. 语义、语法任务相关的脑功能磁共振成像[J]. 中国医学影像技术，2012，28（5）：865-868.
[7]Meyer PT, Sturz L, Schreckenberger M, et al. Preoperative mapping of cortical language areas in adult brain tumour patients using PET and individual non-normalised SPM analyses[J]. Eur J Nucl Med Mol Imaging, 2003, 30(7): 951-960.
[8]Partovi S, Jacobi B, Rapps N, et al. Clinical standardized fMRI reveals altered language lateralization in patients with brain tumor[J]. AJNR, 2012, 33(11): 2151-2157.
[9]Ward NS, Brown MM, Thompson AJ, et al. Neural correlates of outcome after stroke: a cross-sectional fMRI study[J]. Brain, 2003, 126(Pt 6): 1430-1448.
[10]Thompson CK, den Ouden DB. Neuroimaging and recovery of language in aphasia[J]. Curr Neurol Neurosci Rep, 2008, 8(6): 475-483.
[11]Wang L, Chen D, Yang X, et al. Group independent component analysis and functional MRI examination of changes in language areas associated with brain tumors at different locations[J]. PLoS One, 2013, 8(3): e59657.
[12]Fernandez B, Cardebat D, Demonet JF, et al. Functional MRI follow-up study of language processes in healthy subjects and during recovery in a case of aphasia[J]. Stroke, 2004, 35(9): 2171-2176.
[13]吴陈兴，魏淼，仪晓立，等. 累及Broca区低级别胶质瘤的BOLD-fMRI及语言功能区的可塑性研究（附15例分析）[J]. 中国微侵袭神经外科杂志，2009，14（1）：10-13.