Abstract Objective: To analysis the diagnostic value of 18F-FDG PET/CT in adult-onset still’s diseases(AOSD) and its characteristics in PET/CT. Methods: According to the diagnostic criteria of 1992 in adult-onset still’s diseases research committee of Japan, the clinical data and PET/CT images of 50 patients with AOSD were retrospectively analyzed in rheumatology department of the PLA general hospital. We summarized characteristics and advantages in the PET/CT imaging of AOSD. Results: Among the 50 AOSD patients, no patient was found with solid malignant tumors. Various degrees of FDG uptake were found in liver, spleen, bone marrow, lymph nodes, joint and glands. Uptake in Bone marrow was seen in 41 patients(SUVmax: 3.60±1.02), 29 of which had undergone bone marrow biopsy. Uptake in lymph node was seen in 30 patients(SUVmax: 5.86±3.79), 9 of which had undergone lymph node biopsy, and all of the pathological results turned out to be lymphoid tissue hyperplasia. Maximum diameters of lymph nodes which were measured in transverse CT images were 0.68~2.54 cm. Uptake in spleen(SUVmax: 3.35±0.94), liver(SUVmax: 2.56±0.66), joints(SUVmax: 2.46±0.81) and gland(SUVmax: 2.37±0.79) was seen in 39, 11, 5 and 14 patients. Maximum diameters obliqua of right lobe of liver which were measured in transverse CT images were 14.2~23.5 cm. No significant FDG uptake and subcutaneous nodules were found in all of the 50 AOSD patients. Conclusion: Whole body 18F-FDG PET/CT performs an important role in diagnosis of AOSD. Characteristic manifestations in 18F-FDG PET/CT help to exclude malignant diseases or to guide the biopsy and clinical management of ASOD.
SHEN Zhi-hui,LIU Ya-chao,DU Lei, et al. Application of PET/CT diagnosis in adult-onset Still’s diseases[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2016, 27(9): 659-662.
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2016, Vol. 27 
