酰胺质子转移成像的临床应用及挑战

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Abstract In recent years, amide proton transfer(APT) imaging, as a new modality of MR imaging, has attracted more and more attention in clinical applications. APT imaging can detect the exchange characteristics of amide protons in free proteins and peptides and water protons by means of water signal changes. APT imaging can reflect tumor, stroke, neonatal hypoxic-ischemic encephalopathy related to protein and pH at the molecular level. In addition to the nervous system, APT imaging has now been used in several other systems. APT imaging, as an in vivo, noninvasive, cellular and molecular level MR imaging modality without exogenous contrast agents, can provide more information for clinical studies and will be further developed in future studies.

Key words： Central nervous system diseases Magnetic resonance imaging

Received: 11 July 2017

PACS:	Ｒ742
	Ｒ445.2

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	WANG Xiao-ming
	ZHENG Yang

Cite this article:

WANG Xiao-ming,ZHENG Yang. Clinical application and challenges of amide proton transfer imaging[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2017, 28(10): 692-696.

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http://www.jccmi.com.cn/EN/ OR http://www.jccmi.com.cn/EN/Y2017/V28/I10/692

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