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| BOLD-fMRI study on the function analysis of the brain in major depression disorder and#br#
their first-degree relatives |
| SONG Yu-lu1, MU Xin-nuan2, SONG Xiao-lei1, FANG Jun-fang2, MAO Ning3, WANG Bin1 |
1. Department of Radiology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai Shandong 264003, China;
2. Medical Imaging Center of Binzhou Affiliated Hospital of Binzhou Medical University, Binzhou Shandong 256600, China;
3. Yantai Yuhuangding Hospital, Yantai Shandong 264000, China |
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Abstract Objective: We studied the characteristics and differences of the regional homogeneity(ReHo) of the major depression disorder(MDD) and their first-degree relatives in the resting state by functional magnetic resonance imaging(fMRI), in order to understand the early changes of the brain function in patients with MDD. Methods: The experiments were performed by 3.0T fMRI in 15 patients with MDD(the depression group), 15 first-degree relatives of MDD(the first-degree relatives group) and 15 healthy volunteers(the control group). A statistics analysis of ReHo was performed subsequently. Results: The ReHo values measured in right middle frontal gyrus, right precentral gyrus, right superior frontal gyrus, right anterior cingulate cortex, right insular, left putamen, left superior temporal gyrus, left middle temporal gyrus, left dorsal cingulate cortex of MDD group were significantly lower than those of the first-degree relatives group(P<0.05). The ReHo values measured in left postcentral gyrus, left superior temporal gyrus, left middle temporal gyrus, left inferior frontal gyrus, left orbitofrontal cortex, left dorsal cingulate cortex, right precentral gyrus, right medial prefrontal cortex, right superior frontal gyrus, the middle frontal gyrus, the anterior cingulate cortex, right insular of MDD group were significantly lower than those of the control group(P<0.05). The ReHo values measured in left anterior lobe of cerebellum, left middle temporal gyrus, left inferior frontal gyrus, left orbitofrontal cortex, left superior frontal gyrus, left dorsal cingulate cortex, left insular, right middle frontal gyrus, right anterior cingulate cortex of the first-degree relatives group were significantly lower than those of the control group(P<0.05). Conclusion: With the widespread abnormal ReHo values of brain in MDD and first-degree relatives, we can get a hypothesis that these abnormalities may be associated with cognitive network disorders and emotional distress in MDD.
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Received: 23 December 2016
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