多模态MRI在宫颈癌放疗后疗效评估中的价值

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Abstract Objective: To investigate the value of multimodal MRI in the evaluation of the efficacy of radiotherapy for cervical cancer. Methods: We selected 44 cases of biopsy confirmed cervical cancer patients with radiation therapy as observation group, and 15 cases of healthy women(cervical lesions were not found in gynecological and ultrasound) as control group. All patients underwent conventional MRI, DWI(b value of 800 s/mm2) and dynamic enhanced MRI. Then we analyzed the dynamic curve, early enhancement rate, average ADC value and minimum ADC value. Results: The average ADC value of observation group was (1.078±0.242)×10-3 mm2/s, minimum ADC value was (0.939±0.093)×10-3 mm2/s. The results of two groups were statistically significant(P<0.05). After radiotherapy, the minimal ADC value was (1.002±0.011)×10-3 mm2/s of the residual tumor group(before radiotherapy), and the minimum ADC value was (0.863±0.078)×10-3 mm2/s of the residual tumor group(before radiotherapy) were statistically significant(P<0.05) in the two groups. The minimum ADC value of radiotherapy group was (0.939±0.093)×10-3 mm2/s, the minimum ADC value was (1.368±0.113)×10-3 mm2/s after radiotherapy, there was significant difference between the two groups(P<0.05). The mean ADC value of the normal group was (1.873±0.027 4)×10-3 mm2/s, and the minimum ADC value was (1.368±0.113)×10-3 mm2/s after radiotherapy in the radiotherapy group, the difference was statistically significant(P<0.05). The early enhancement rate of normal cervix was about 3%, and the early enhancement rate of cervical cancer radiotherapy group was about 55.57%, the difference between the two groups was statistically significant(P<0.05). The early enhancement rate after radiotherapy was about 10.46%, which was significantly different from that before radiotherapy(P<0.05). The time-signal intensity curve(TIC) of the normal group showed an inflow pattern. The TIC of cervical cancer radiotherapy group was mostly platform type(40/44), and most of them were inflow type(38/44) after radiotherapy. The difference between the two groups was statistically significant(P<0.05). Conclusion: The minimum ADC value, early enhancement rate analysis, semi quantitative TIC curve of cervical cancer before and after radiotherapy by multimodal MRI have very important clinical significance and value in the evaluation of diagnosis and treatment of cervical cancer.

Key words： Cervix neoplasms Radiotherapy Magnetic resonance imaging

Received: 10 March 2017

PACS:	Ｒ737.33
	Ｒ730.55
	Ｒ445.2

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	Articles by authors
	WANG Wei-qing1
	WU Xia1
	FU Bao-cheng1
	HUANG Yong2
	CAO Guang-hui1

Cite this article:

WANG Wei-qing1,WU Xia1,FU Bao-cheng1, et al. The value of multimodal MRI in evaluating the efficacy of radiotherapy for cervical cancer[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2017, 28(12): 872-876.

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http://www.jccmi.com.cn/EN/ OR http://www.jccmi.com.cn/EN/Y2017/V28/I12/872

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