超声量化指标评价白藜芦醇对大鼠肝纤维化的影响

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Abstract Objective: To investigate the effection of resveratrol(RES) on the CCl4-induced liver fibrosis in rat model by ultrasound quantitative index. Methods: Twenty male Sprague-Dawley rats were randomly divided into four groups: control group, RES group, model group, and RES intervention group. The proximal and distal diameter, blood flow velocity of portal vein and liver tissue Young’s modulus were detected by ultrasonography. The degree of hepatic fibrosis was determined under light microscope after HE stained. Results: ①After RES intervention, the symptoms of rats were mild with the weight increase, and the liver fibrosis was improved. ②In model and RES intervention group, the portal vein proximal and distal diameter, Young’s modulus of liver tissue were increased compared with control and RES group(P<0.05); The portal vein blood flow velocity was increased, but the differences among the groups were not statistically significant(P>0.05). The changes of the portal vein diameter and Young’s modulus were decreased after RES intervention. There were no significant differences between the control and RES group(P>0.05). Conclusion: ①RES can effectively improve the pathological changes of CCl4-induced liver fibrosis. ②Portal vein diameter and Young’s modulus can effectively evaluate the effect of RES on CCl4-induced liver fibrosis in rat.

Key words： Liver cirrhosis Rats Ultrasonography

Received: 20 September 2016

PACS:	Ｒ657.31
	Ｒ445.1

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	Articles by authors
	SANG Liang
	WANG Xue-mei
	XU Dong-yang
	SHANG Gong-qun
	YUAN Sheng-mei
	TU Shu-xing

Cite this article:

SANG Liang,WANG Xue-mei,XU Dong-yang, et al. Evaluation of the effect of resveratrol on liver fibrosis in rat by ultrasound quantitative index[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2017, 28(4): 255-259.

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http://www.jccmi.com.cn/EN/ OR http://www.jccmi.com.cn/EN/Y2017/V28/I4/255

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