二维斑点追踪技术评价兔急、慢性心肌梗死心肌圆周应变

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Abstract Objective: To evaluate the global myocardial circumferential strain and strain rate in rabbits with acute and chronic myocardial infarction by two-dimensional speckle tracking imaging. Methods: Twenty New Zealand rabbits with ligation of the left circumflex artery were observed as experimental group and 5 rabbits without ligation of the artery as control group. The degree of global myocardial circumferential strain(GCS) and strain rate(GSrC) at mitral valve, papillary muscle and apical level were compared by speckle tracking imaging before, one week and seven weeks after surgery, respectively. And the fate of the animals, cardiac magnetic resonance imaging(cMRI) and triphenyltetrazolium chloride(TTC) staining were studied for myocardial infarction sizes(MI size%). Results: Compared with the preoperative parameters, there were significant increases in GCS and GSrC one week after the surgery(P<0.05) at mitral valve level. Compared with those parameters 1 week postoperative, there were significant decreases in GCS and GSrC at the 7th week postoperative(P<0.05), which had no obvious changes than those of the basic status. Compared with the preoperative parameters, there were significant decreases in GCS and GSrC at the 1st and 7th week postoperative at papillary muscle and apical level(P<0.05), but there was no significant difference between the 1st and the 7th week postoperative. Conversely there were no much changes of the degree of GCS and GSrC of myocardium at each time point in the control group(P>0.05). The degree of GCS and GSrC of myocardium at papillary muscle level had correlations with LVEF(US), LVEF(cMRI) and MI size%(r=-0.943, -0.916, -0.749, -0.615, 0.807, 0.641, respectively, all P<0.05). Conclusion: Two-dimensional speckle tracking imaging can objectively quantify regional and global heart function in rabbits, and can help to analyze the location and size of the myocardial infarction.

Key words： Myocardial infarction Echocardiography, Doppler, color

Received: 29 September 2016

PACS:	Ｒ542.23
	Ｒ540.45

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	Articles by authors
	ZHOU Meng1
	WU Jun1
	FENG Yuan-bo2
	QIN Hao-cheng1
	LI Jie-ming1
	WEN Xiao-na1
	NI Yi-cheng2

Cite this article:

ZHOU Meng1,WU Jun1,FENG Yuan-bo2, et al. Evaluation of circumferential strain in rabbits with acute and chronic myocardial infarction by#br# two-dimensional speckle tracking imaging[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2017, 28(6): 420-424.

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http://www.jccmi.com.cn/EN/ OR http://www.jccmi.com.cn/EN/Y2017/V28/I6/420

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