结直肠原发神经内分泌癌的CT表现

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Abstract Objective: To explore the CT findings of primary colorectal neuroendocrine carcinomas(NECs), and to improve the imaging diagnosis of them. Methods: CT findings of 32 patients with primary colorectal NECs and 46 patients with colorectal adenocarcinoma confirmed by surgery and pathology were analyzed retrospectively. The differences of age, gender, tumor location, size of the lesion, the thickening pattern of the intestinal wall, the pattern of contrast-enhancement, the peri-intestinal invasion, the occurrence of intestinal obstruction and metastasis to other organs were compared between the two groups. Results: Compared with the colorectal adenocarcinoma group, patient of colorectal NECs group was younger(t=3.634, P<0.001). There were statistically significant differences of focal thickening, size of the lesion and contrast-enhancement(P<0.05). While in gender, lesion location, occurrence of intestinal obstruction, lymph node metastasis, or metastasis, there was no statistically significant difference(P>0.05). Conclusion: Primary colorectal NECs are often found in young patients. Their CT manifestations include a polypoid lesion and is characterized by significant contrast-enhancement. Significantly contrast-enhanced metastasis may occur in liver.

Key words： Colorectal neoplasms Endocrine gland neoplasms Tomography, spiral computed

Received: 27 September 2016

PACS:	Ｒ735.35
	Ｒ735.37
	Ｒ730.264
	Ｒ814.42

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	Articles by authors
	LI Zhen-hui
	ZHANG Zhi-ping
	DONG Xing-xiang
	YANG Guang-jun
	GAO De-pei
	ZHANG Da-fu

Cite this article:

LI Zhen-hui,ZHANG Zhi-ping,DONG Xing-xiang, et al. CT features of colorectal neuroendocrine carcinomas[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2017, 28(6): 430-433.

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http://www.jccmi.com.cn/EN/ OR http://www.jccmi.com.cn/EN/Y2017/V28/I6/430

[1]Kl?觟ppel G, Perren A, Heitz PU. The gastroenteropancreatic neuroendocrine cell system and its tumors: the WHO classification[J]. Ann N Y Acad Sci, 2004, 1014(1): 13-27.
[2]Bosman FT, Carneiro F, Hruban RH, et al. WHO classification of tumours of the digestive system[M]. Lyon: Iarc Press, 2010: 60-65.
[3]廖波，魏少忠，黄小辉. 结直肠神经内分泌肿瘤25例临床分析[J]. 中华结直肠疾病电子杂志，2016，5（5）：440-443.
[4]Auernhammer CJ, G?觟ke B. Therapeutic strategies for advanced neuroendocrine carcinomas of lejunum/ileum and pancreatic origin[J]. Gut, 2011, 60(7): 1009-1021.
[5]Haeubl M, Schuerz S, Svejda B, et al. Asymmetrically substituted cationic indole- and fluorene porphyrins inhibit tumor proliferation in small intestinal neuroendocrine tumors and medullary thyroid carcinomas[J]. Eur J Med Chem, 2010, 45(2): 773-760.
[6]Fraenkel M, Kim MK, Faggiano A, et al. Epidemiology of gastroenteropancreatic neuroendocrine tumours[J]. Best Pract Res Clin Gastroenterol, 2012, 26(6): 691-703.
[7]Chang S, Choi D, Lee SJ, et al. Neuroendocrine neoplasms of the gastrointestinal tract: classification, pathologic basis, and imaging features[J]. Radiographics, 2007, 27(6): 1667-1679.
[8]蒋梦捷，胡涵光，郑树，等. 结直肠神经内分泌肿瘤诊治进展[J]. 中华结直肠疾病电子杂志，2014，3（5）：43-46.
[9]Cho MY, Kim JM, Jin HS, et al. Current trends of the incidence and pathological diagnosis of gastroenteropancreatic neuroendocrine tumors(GEP-NETs) in Korea 2000-2009: multicenter study[J]. Cancer Res Treat, 2012, 44(3): 65-157.
[10]Shafqat H, Ali S, Salhab M, et al. Survival of patients with neuroendocrine carcinoma of the colon and rectum: a population-based analysis[J]. Dis Colon Rectum, 2015, 58(3): 294-303.
[11]Schott M, Kl?觟ppel G, Raffel A, et al. Neuroendocrine neoplasms of the gastrointestinal tract[J]. Dtsch Arztebl Intern, 2011, 108(18): 305-312.
[12]Richards D, Davis D, Yan P, et al. Unusual case of small cell gastric carcinoma: case report and literature review[J]. Dig Dis Sci, 2011, 56(4): 951-957.
[13]Grabowski P, Sch?觟nfelder J, Ahnert-Hilger G, et al. Expression of neuroendocrine markers: a signature of human undifferentiated carcinoma of the colon and rectum[J]. Vrichows Arch, 2002, 441(3): 256-263.
[14]Vortmeyer AO, Lubensky IA, Merino MJ, et al. Concordance of genetic alterations in poorly differentiated colorectal neuroendocrine carcinomas and associated adenocarcinomas[J]. J Natl Cancer Inst, 1997, 89(19): 1448-1453.
[15]Wang D, Zhang GB, Yan L, et al. CT and Enhanced CT in diagnosis of gastrointestinal neuroendocrine carcinomas[J]. Abdom Imaging, 2012, 37(5): 738-745.
[16]李关宁，杨振淮. 结直肠神经内分泌癌15例临床诊治分析[J]. 消化肿瘤杂志：电子版，2016，8（1）：28-32.
[17]梁振威，蒋力明，李颖，等. 直肠神经内分泌肿瘤的影像学分析[J]. 中华肿瘤防治杂志，2015，22（11）：867-870.
[18]董锐增，师英强，叶延伟，等. 23例胃低分化神经内分泌癌的临床病理特点和预后分析[J]. 中华外科杂志，2010，13（8）：583-586.
[19]Kaltsas G, Rockall A, Papadogias D, et al. Recent advances in radiological and radionuclide imaging and therapy of neuroendocrine tumours[J]. Eur J Endocrinol, 2004, 151(1): 15-27.
[20]Cwikla JB, Nasierowska-guttmejer A, Jeziorski KG, et al. Diagnostic imaging approach to gastro-entero-pancreatic carcinomas of neuroendocrine origin-single net center experience in Poland[J]. Neuro Endocrinol Lett, 2007, 28(28): 789-800.
[21]Kim SY, Byun JH, Choi G, et al. A case of primary paraganglioma that arose in the pancreas: the color Doppler ultrasonography and dynamic CT features[J]. Korean J Radiol, 2008, 9(Suppl): 18-21.
[22]Badea R, Seicean A, Diaconu B, et al. Contrast-enhanced ultrasound of the pancreas—a method beyond its potential or a new diagnostic standard?[J]. J Gastrointestin Liver Dis, 2009, 18(2): 237-242.
[23]Suresh PK, Sahu KK, Pai RR, et al. The prognostic significance of neuroendocrine differentiation in colorectal carcinomas: our experience[J]. J Clin Diag Res, 2015, 9(12): 1-4.