声脉冲辐射力成像技术评估肝细胞癌射频消融术后24 h疗效的价值

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Abstract Objective: To explore the role of acoustic radiation force impulse(ARFI) in assessing the therapeutic response 24 h after radiofrequency ablation(RFA) in hepatocellular carcinoma(HCC). Materials and Methods: A total of 22 patients with 23 HCC lesions who received RFA in our hospital from December 2015 to June 2016 were enrolled. All the patients were examined with base-line ultrasound(BUS), contrast enhanced ultrasound(CEUS) and ARFI one day before RFA, 24 h after RFA and one month after RFA, respectively. The change of ablation area stiffness was measured by virtual touch tissue quantification(VTQ). The ablation lesion area was measured by BUS, virtual touch tissue imaging(VTI) and CEUS. The area of ablation lesions measured by the three methods were compared. Results: Twenty-three tumors showed low-echo on VTI 24 h after RFA and one month after RFA, which were easily detected. The extent of ablation area was enlarged compared to preoperative. After 24 h of RFA procedure, the VTQ value of the internal and marginal ablation lesion area was higher than preoperative(all P<0.01), respectively, but there was no statistically significant difference for one month after RFA(P=0.46, P=0.50). The value of VTQ in peripheral parts of the primary tumor did not change significantly at one week before RFA, 24 h after RFA or one month after RFA(all P>0.05). The ablation lesion areas 24 h after RFA and one month after RFA measured by VTI and CEUS were larger than that by BUS(all P<0.01). However, there was no statistically significant difference of ablation lesion area between VTI and CEUS(P=0.88, P=0.49). Conclusion: ARFI, as a non-invasive, effective and feasible method, can accurately measure the ablation area and provide the change of lesion stiffness immediately after RFA of HCC.

Key words： Carcinoma, hepatocellular Catheter ablation Ultrasonography, Doppler, color

Received: 25 October 2016

PACS:	Ｒ735.7
	Ｒ445.1

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http://www.jccmi.com.cn/EN/ OR http://www.jccmi.com.cn/EN/Y2017/V28/I7/488

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