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| Evaluation of non-alcoholic fatty liver disease and prediction of liver fibrosis by 3.0T magnetic resonance elastography |
| ZHANG Xian-yi, JI Ruo-yun, CAI Xiao-li, SHI Yu |
| Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110004, China |
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Abstract Objective: To investigate the effect of 3.0T magnetic resonance elastography(MRE) on the evaluation of non-alcoholic fatty liver disease(NAFLD) patients and prediction the liver fibrosis. Methods: The preoperative liver stiffness of 20 healthy volunteers(normal group) and 57 patients(pathological group) diagnosed with NAFLD by liver biopsy were analyzed by 3.0T MRE. Receiver operating characteristic curve(ROC) was used to evaluate the diagnostic efficacy of MRE in the staging liver fibrosis. Results: The shear stiffness of the normal group and the pathological group were (1.97±0.43) kPa and (4.05±1.70) kPa, with statistical significance(t=-8.518, P<0.001). The AUC of MRE for diagnosising ≥F1, ≥F2, ≥F3 and F4 liver fibrosis in NAFLD patients was 0.92, 0.94, 0.95 and 0.99, respectively, all of which were higher than that of NFS(0.74, 0.81, 0.85 and 0.91, respectively). Conclusion: MRE is a reliable tool for the evaluation of different stages of fibrosis in NAFLD patients.
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