初探R2*值定量评估子宫内膜癌生物学行为的价值

doi:10.12117/jccmi.2019.02.013

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Abstract Objective: To explore the biological behavior of endometrial carcinoma(EC) by analysing the correlation between the R2* value of enhanced T2 star-weighted angiography(ESWAN) sequence and the pathological type, depth of myometrium infiltration, vascular invasion, invasion and metastasis of EC. Methods: We retrospectively analyzed the imaging data of 122 cases who were diagnosed as EC by postoperative pathology and underwent 1.5T MRI examination(including ESWAN sequence). The R2* values of EC lesions were measured. All patients were divided into four pairing groups: the high-risk pathological type group(type Ⅰ grade 3 and type Ⅱ, group A1) and low-risk pathological type group(type Ⅰ grade 1 and grade 2, group B1), deep myometrial invasion group(group A2) and non deep myometrial invasion group(group B2), vascular invasion group(group A3) and non vascular invasion group(group B3), invasion and metastasis group(stage Ⅱ, Ⅲ and Ⅳ, group A4) and non invasion and metastasis group(stage Ⅰ, group B4). The R2* values of the paired groups were compared by independent sample t test. The diagnostic efficiency of R2* in the diagnosis of EC high-risk pathological type, deep myometrial invasion, vascular invasion, invasion and metastasis was evaluated by receiver operator characteristic(ROC) curve, and the corresponding thresholds were found. Results: There were 40 cases in group A1, 82 cases in group B1, 44 cases in group A2, 78 cases in group B2, 25 cases in group A3, 97 cases in group B3, 27 cases in group A4 and 95 cases in group B4. The R2* values of the four pairing groups were (17.60±4.02) vs. (12.81±2.66) Hz, (17.57±3.96) vs. (12.58±2.40) Hz, (18.62±4.68) vs. (13.29±2.75) Hz, (18.33±4.22) vs. (13.26±2.94) Hz, respectively, and the differences had statistically significant(t=6.840, 7.613, 5.456, 5.858, P<0.001). The AUC of R2* values for EC high-risk pathological type, deep myometrial invasion, vascular invasion, invasion and metastasis were 0.856, 0.876, 0.834 and 0.855, respectively. The thresholds for predicting high-risk pathological type, deep myometrial invasion, vascular invasion, invasion and metastasis of EC were R2* value≥15.24 Hz, R2* value≥14.76 Hz, R2* value≥14.67 Hz, R2* value≥15.25 Hz, respectively. The sensitivity and specificity were 77.50% and 84.00%, 82.90% and 68.00%, 79.50% and 85.20%, 79.50% and 76.80%, respectively. Conclusion: R2* value can be used as a quantitative index for evaluating the biological behavior of EC in non-enhancement MR.

Key words： Endometrial neoplasms Magnetic resonance imaging

Received: 13 February 2018

PACS:	Ｒ737.33
	Ｒ445.2

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	Articles by authors
	TIAN Shi-feng
	LIU Ai-lian
	SONG Qing-wei
	LIU Jing-hong
	SUN Mei-yu
	ZHU Wen

Cite this article:

TIAN Shi-feng,LIU Ai-lian,SONG Qing-wei, et al. The value of R2* in quantitative evaluation of the biological behavior of endometrial carcinoma: a preliminary study[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2019, 30(2): 126-130.

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http://www.jccmi.com.cn/EN/10.12117/jccmi.2019.02.013 OR http://www.jccmi.com.cn/EN/Y2019/V30/I2/126

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