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| The value of T2-MRI whole tumor histogram analysis for differenting astrocytoma from ependymoma in children |
| LV Qing-qing, ZHANG Yong, CHENG Jing-liang, ZHU Chen-di, WANG Wei-jian, XU Ke |
| Department of MRI, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China |
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Abstract Objective: To investigate the value of histogram analysis derived from T2-MRI imaging in differentiating astrocytoma from ependymoma in children. Methods: Retrospective analysis of pathologically confirmed 85 cases of posterior fossa tumors was performed, including 36 cases of astrocytoma and 49 cases of ependymoma. After drawing the region of interest on each slice of T2-MRI maps including tumor and doing the histogram analysis, we can get mean, variance, skewness, kurtosis, the 1st, 10th, 50th, 90th, 99th percentile characteristics. The histogram parameters were analyzed statistically to find out the characteristics of the significant differences between the two groups. Then, the ROC curve was drawn to assess diagnostic efficiency. Result: As for the 9 parameters extracted from histogram, the differences of the variance, skewness, kurtosis and the 50th percentiles between the two groups showed statistical significance(P<0.05). Areas under the ROC curve were 0.668, 0.744, 0.679, and 0.651, respectively. The sensitivity and the specificity of differentiation for variance were 61.1% and 61.2% respectively. For skewness, kurtosis and the 50th percentile, the sensitivity and the specificity were 69.4% and 77.8%, 65.3% and 69.4%, 61.1% and 61.2% respectively. Conclusion: T2-MRI whole tumor histogram analysis can provide more quantitative information characteristics, which provides a new method for the differential diagnosis of children with astrocytoma and ependymoma.
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Received: 17 March 2018
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