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| Assessment of left ventricular systolic function by three-dimensional speckle tracking imaging in#br#
patients with type-2 diabetes mellitus |
| ZHAO Yan-jie1, WEN De-hui2, ZHENG Ying-juan2, LIU Wei-liang2 |
1．Hebei North University, Zhangjiakou Hebei 075000, China; 2．Department of Ultrasonography,
The First Affiliated Hospital of Hebei North University, Zhangjiakou Hebei 075000, China |
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Abstract Objective: To evaluate the myocardial systolic function of the left ventricle in patients with type 2 diabetes mellitus(T2DM) by using three-dimensional speckle tracking imaging(3D-STI) and to explore the possible predictors of early myocardial damage. Methods: 44 patients with early type 2 diabetes(DM group) and 40 healthy volunteers with gender and age matching(control group) were collected. Conventional two-dimensional echocardiography was used to measure and compare conventional parameters. Meanwhile, 3D-STI was applied to measure the left ventricle global longitudinal strain(GLS), global radial strain(GRS), global circumferential strain(GCS) and global area strain(GAS). The clinical value of the global three-dimensional strain parameters(simultaneously adding new parameters derived from GLS, GCS, GRS and GAS through binary Logistic regression, defined as "predictive parameters") in diagnosing left ventricular systolic function damage in T2DM patients was analyzed by receiver operating characteristic curve(ROC). Results: Compared with the control group, the left ventricle GLS, GRS, GCS and GAS in the DM group were significantly reduced, with statistically significant differences(P<0.05). The ROC curve showed that the areas under the curve of "predicted parameter" and GLS were larger. When the "predicted parameter" was 0.56% as cut-off point, the sensitivity and specificity were 86% and 85%, and the Youden index was 0.71. When GLS was -18.35 as cut-off point, the sensitivity and specificity were 93% and 62%, and the Youden index was 0.56. Conclusion: 3D-STI can early assess the changes of left ventricular global systolic function in patients with T2DM, and the left ventricular myocardial systolic function is significantly reduced in patients. Meanwhile, "predictive parameters" can be used as good predictors for early myocardial injury in patients with T2DM.
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Received: 29 October 2018
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2019, Vol. 30 
