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| Changes of cerebral blood flow perfusion and cerebral gray matter volume in mild Alzheimer’s disease |
| ZHANG Kun-long, LI Wei-shuai, SUN Hong-zan, NAO Jian-fei, ZHENG Dong-ming |
| Shengjing Hospital of China Medical University, Shenyang 110004, China |
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Abstract Objective: To investigate the changes of cerebral blood perfusion and gray matter volume in patients with mild Alzheimer’s disease(AD). Methods: Magnetic resonance imaging(MRI) scanning including 3D-T1WI and 3D pseudo-continuous arterial spin labeling(3D-pcASL) sequences was performed in patients with mild Alzheimer’s disease and cognitively normal elderly. Statistical analysis of the differences of whole brain perfusion based on voxel in cerebral blood flow(CBF) map of the whole brain of the two groups of subjects was performed using Statistical Parametric Mapping(SPM) 8 software. Voxel-based morphometry(VBM) was used to compare the difference of whole brain gray matter volume between the two groups. Correlation analysis was performed between the CBF of the brain region with different perfusion and the Mini-mental State Examination(MMSE) score. Results: A total of 26 patients with mild AD(age (73.0±6.8) years, 16 males) and 53 age-sex matched healthy controls(age (73.7±8.2) years, 23 males) were included. Compared with the normal control group, the decreased CBF perfusion areas in the mild AD group were mainly located in the bilateral parietal lobe(precuneus, angular gyrus), occipital lobe and left temporal lobe and frontal lobe, the increased CBF perfusion areas were mainly located in the right hippocampus and parahippocampal gyrus, right cingulate gyrus and basal ganglia and bilateral frontal lobes(orbitalis and medial side)(P<0.01, FDR correction, Bulk threshold>100 pixels). The gray matter atrophy in patients with mild AD was mainly located in the bilateral medial temporal lobe structure(hippocampus, parahippocampal gyrus, amygdala), and also involved the bilateral insular lobes and basal ganglia nuclei(P<0.01, FDR correction, Bulk threshold>100 pixels). The CBF values of the left temporal parietal gyrus and bilateral superior frontal gyrus were positively correlated with the MMSE scores in the mild AD group. The CBF values of the bilateral medial and lateral cingulate gyrus and the right anterior cingulate gyrus were negatively correlated with the MMSE scores(P<0.05). Conclusion: In mild AD patients, there are mainly low perfusion in the parietal lobe and high perfusion in the hippocampus, basal ganglia and frontal lobe, while gray matter atrophy is mainly concentrated in the medial structures of bilateral temporal lobes.
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Received: 02 August 2019
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