系统性红斑狼疮患者脑小血管病变的MRI初步研究

doi:DOI:10.12117/jccmi.2020.04.002

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Abstract Objective: To evaluate MRI findings of enlarged perivascular space(EPVS), white matter hyperintense (WMH) and lacunes of cerebral small vessel disease(CSVD) in patients with systemic lupus erythematosus(SLE). Materials and Methods: Twenty-nine SLE patients and twenty-nine age- and sex-matched healthy subjects participated in this retrospective study. EPVS, WMH, and lacunes were rated by two radiologists. SPSS 24.0 was used for data statistical analysis, Kolmogorov-Smirnov Z test was used to analyze group difference, and Spearman correlation analysis was used to analyze the correlation between CSVD and clinical and laboratory examination. Results: In the centrum semiovale(CS), the EPVS score in the SLE group was higher than that in the control group(2.52±0.91, 1.34±0.55, P<0.01). The periventricular hyperintense(PVH) and deep white matter hyperintense(DWMH) in the SLE group were more significant than those in the control group(P<0.01), and the incidence of lacunes in SLE group was higher than that in the control group(P<0.05). In SLE group, EPVS in the CS and PVH were correlated with complement C3(r=0.505, 0.400, P<0.05), EPVS score and WMH were positively correlated with disease duration(r=0.460, 0.428, 0.416, 0.404, P<0.05). Conclusion: Cerebral small vessel disease is a common manifestation of central nervous system lesions in SLE patients and is associated with complement C3 and disease duration.

Key words： Lupus erythematosus, systemic Cerebrovascular disorders Magnetic resonance imaging

Received: 18 July 2019

PACS:	R593.24
	Ｒ743
	Ｒ445.2

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	Articles by authors
	CHE Yi-wei
	MIAO Yan-wei
	JIANG Yu-han
	CHANG Pei-pei
	SONG Qing-wei

Cite this article:

CHE Yi-wei,MIAO Yan-wei,JIANG Yu-han, et al. MRI findings of cerebral small vessel disease in patients with systemic lupus erythematosus[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2020, 31(4): 234-237.

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http://www.jccmi.com.cn/EN/DOI:10.12117/jccmi.2020.04.002 OR http://www.jccmi.com.cn/EN/Y2020/V31/I4/234

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