T1 mapping成像在宫颈癌组织分化程度评估中的初步应用

doi:DOI:10.12117/jccmi.2020.04.011

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Abstract Objective: To explore the value of T1 mapping in assessing grades of uterine cervical cancer. Methods: Seventy patients with pathologically proven cervical cancer and 30 patients with normal cervix underwent conventional MRI and DWI before therapy. Seventy cases of cervical cancer, including 56 cases of squamous cell carcinoma and 14 cases of adenocarcinoma, were divided into well/moderately differentiated tumor group(n=49) and poorly differentiated tumor group(n=21) according to the degree of pathological differentiation. Look-Locker sequences were performed pre and post contrast separately at 5 min after Gd-DTPA administration. T1 relaxation times(T1pre and T1post) and ADC of tumor and normal cervix were measured. The differences in the parameters between cervical cancer and normal cervix, tumor types/grades were compared, and ROC curve was drawn with statistically significant parameters. Results: The difference of T1pre, T1post and ADC was statistically significant between cervical cancer and normal cervix(P＜0.001). There was no significant difference in T1pre, T1post and ADC between squamous cell carcinomas and adenocarcinomas. Compared to the well/moderately differentiated tumor group, poorly differentiated tumor group showed increased T1post and decreased ADC(P=0.000 and P=0.002, respectively). No significant difference was observed for T1pre in differentiated grades of tumor. The areas under ROC curve of T1post and ADC for diagnosis of well/moderately and poorly differentiated tumor were 0.766 and 0.736. Conclusion: Enhanced T1 mapping can reflect the degree of tissue differentiation of cervical cancer to a certain extent.

Key words： Cervix neoplasms Magnetic resonance imaging

Received: 27 June 2019

PACS:	Ｒ737.33
	Ｒ445.2

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	Articles by authors
	LI Shu-jian
	CHENG Jing-liang
	ZHANG Yong
	LIU Jie
	YANG Meng
	ZHANG Fei-fei

Cite this article:

LI Shu-jian,CHENG Jing-liang,ZHANG Yong, et al. T1 mapping in evaluation of differentiation of cervical cancer: a primary study[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2020, 31(4): 276-280.

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http://www.jccmi.com.cn/EN/DOI:10.12117/jccmi.2020.04.011 OR http://www.jccmi.com.cn/EN/Y2020/V31/I4/276

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