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| Evaluation on angiogenesis of benign and malignant breast tumors with contrast enhanced microvascular imaging |
| LI Ying-jia, WEN Ge, YE Chang-sheng |
| Nanfang Hospital, Nanfang Medical University, Guangzhou 510515, China |
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Abstract Objective: To compare the differences in angiogenetic characteristics of benign and malignant tumors. Methods: Thirty cases with malignant breast carcinoma and 30 cases with fibroadenoma were inspected by ultrasonic contrast enhanced microvascular imaging(MVI). All samples were analysed with microscopy by HE staining. The samples of breast cancers(10 cases), breast fibroadenoma(10 cases) and normal breast tissues(10 cases) were analysed routinely with transmission electronic microscopy. Results: MVI inside of the focus was increased heterogeneously that had the characteristic of malignant tumor such as filling defect and vessel distortion. The newly formed blood vessels of breast cancer were composed of monolayer endothelial cells. The gap between endothelial cells was wide. The basement membrane did not continuous had obvious interstitial edema. The shapes of endothelial cells were abnormal, the cell body became bigger and cytoplasm became richer and abnormal cell nucleus appeared and pinocytotic vesicle increased. Conclusions: The perfusion pattern are valuable diagnostic basis in discriminating benign and malignant breast tumors.
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Received: 24 October 2008
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2009, Vol. 20 
