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| Comparative study of MR DWI and dynamic contrast enhanced MRI fordetection of T1 stage breast cancer |
| HE Cui-ju, LUO Ya-hong, YU Tao, ZHAO Ying-jie, LIU Fan, MAN Jiang-hong, LU Peng |
| Department of Radiology, Liaoning Tumor Hospital, Shenyang 110042, China |
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Abstract Objective: To compare the sensitivity of DWI with dynamic contrast enhanced(DCE） MRI to differentiate small benign breast lesions from T1 stage breast cancers. Materials and Methods: 104 lesions(78 patients) proved by pathology included 79 malignant small lesions(≤2cm) and 25 benign small lesions(≤2cm) underwent DWI and DCE MRI. GE 1.5T MR and breast coil were used. DCE MRI was performed by VIBRANT sequence and time-signal intensity curve(TIC) was drawn. DWI was done with single shot SE-EPI sequence, b=800s/mm2. The apparent diffusion coefficients(ADC) diagnostic threshold between malignant and benign lesions was decided according to receiver operating characteristic curve(ROC). The sensitivity and specificity of DWI for the detection of T1 stage breast cancers were compared with DCE MRI. Results: Seventy-five cases T1 stage breast cancers and 14 cases benign lesions were diagnosed by DCE MRI, the sensitivity and specificity for DCE MRI were 94.9%(75/79) and 76%(19/25). The ADC threshold between malignant and benign lesions was 1.11×10-3mm2/s according to ROC. The sensitivity and specificity for the threshold were 89.9%(71/79) and 88%(22/25). There was significant difference between the malignant and the benign lesion(P<0.05). The sensitivity of DWI ADC value combined plain morphologic features and TIC curve was 91.1%(72/79) in T1 stage breast cancers, and specificity was 88%(22/25). Conclusion: DWI has a high sensitivity for the detection of T1 stage breast cancer, the ADC value is important to diagnose T1 breast cancer.
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Received: 23 December 2008
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2009, Vol. 20 
