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| 3.0T 1H-MRS and MRI volumetry analysis in the hippocampus of children with focal temporal lobe epilepsy |
| SUN He, LIU Zhao-yu, WANG Feng-zhe, WANG Xiao-yu, GUO Qi-yong |
| Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110004, China |
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Abstract Objective: To study the diagnostic value of quantitative proton magnetic resonance spectroscopy(1H-MRS) and volumetric MR(vMR) in the hippocampus of children on focal temporal lobe epilepsy (fTLE), and analyse the relationship between the volume change of the hippocampus and clinical factors. Methods: 3.0T 1H-MRS and vMRI were used to study 30 children(mean age 8.5 years, age 5 to 14 years) with unilateral fTLE, proven by 24 hours active electroencephalogram, and 30 random healthy children(mean age 8.8 years, age 5 to 14 years) served as controls. The spectral resonance lines of N-acetylaspartate (NAA)/creatine(Cr) and volume of the hippocampus were calculated quantitatively on both hippocampal regions of children patients and either side of control group, and then compared among the lesion group, the contralateral group and control group. Explore the relationship between the hippocampus shrink and the seizure frequency etc. Results: The mean concentration of NAA/Cr was significantly decreased in the focus side(1.47±0.24) compared with the nonfocus side(1.79±0.35) and the controls(1.81±0.27), but nonsignificantly between the nonfocus side and controls. Moreover, the mean hippocampal volume of focus side of patients[(2.75±0.35)cm3] was significantly reduced compared with that of nonfocus side[(3.06±0.46)cm3] and the controls[(3.11±0.17)cm3], reference ranges of NAA/Cr and hippocampal volume in control group as standard. Furthermore, seizure frequency has no relation with hippocampus volume shrink in fTLE children. The degree of hippocampus volume reduction was not related with the seizure frequency, but the history of febrile convulsions had significant influence on the hippocampus. Conclusions: 3.0T 1H-MRS and vMRI could be useful for localization in the region of hippocampal lesions, and quantify biochemical metabolic disorders and morphological changes. They could be a complementary modality to provide the reliable information for diagnosis and treatment in fTLE children.
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Received: 28 December 2008
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Corresponding Authors:
中国医科大学盛京医院放射科
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2010, Vol. 21 
