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| Comparative value of transrectal color ＆ power Doppler ultrasonography with microvascular density ofhistopathology by immunochemistry in diagnosing prostate cancer |
| FU Xiao-hong, SHEN Yan, LIU Miao, LIU Qiu-yun, ZHU Zhu-qing, CHEN Ming |
| Department of Ultrasound, Pudong Gongli Hospital, Shanghai 200135, China |
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Abstract Objective: To explore the value of transrectal ultrasound(TRUS), color Doppler flow imaging (CDFI) and power Doppler ultrasonography(PDU) in diagnosing prostate cancer, and correlated with the expression of microvascular density(MVD) in histopathology by immunochemistry. Materials and Methods: In 23 cases of prostate cancer and 21 cases of prostate hyperplasia, the images acquired by two-dimensional(2D) TRUS, CDFI and PDU were analyzed retrospectively. The morphology of prostate was analyzed by 2D sonography. The arterial flow signal of prostate was displayed by CDFI, and the resistance index(RI) was recorded. The classification of arterial flow in the prostate was performed by PDU. And then the MVD expression was detected by immunohistochemistry technique(SP method). Results: ①The accurate rate of TRUS sonography in diagnosing prostate cancer and prostate hyperplasia was 82.6%(19/23) and 90.5%(19/21) respectively. The diagnostic accuracy was increased by 2D sonography combined with CDFI and PDU. ②The classification of arterial flow, RI and MVD expression in prostate cancer were higher than those in prostate hyperplasia with significant difference(P<0.001). The classification of arterial flow by PDU was positively interrelation with MVD expression by immunohistochemistry in prostate cancer. Conclusions: The morphology of prostate was well displayed by 2D TRUS combined with CDFI and PDU, also the classification of arterial flow and RI in prostate were detected. Correlated with the MVD expression, the vascular growth in prostate cancer was confirmed in different aspects. It played a key role in evaluating the biology of prostate cancer.
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Received: 11 November 2009
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2010, Vol. 21 
