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| The study of brain proton magnetic resonance spectroscopy(1H-MRS) in patients with mild cognitive impairment１００８－１０６２（２０11）０1－０001－０5 |
| ZHANG Li-ping, JIANG Gen-di, MIAO Ying-chun, TAN Zhong-jian |
| Dongzhimen Hospital of Beijing Chinese Traditional Medicine University, Beijing 100700, China |
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Abstract Objective: To evaluate the roles of proton magnetic resonance spectroscopy(1H-MRS) in the diagnosis and differential diagnosis of amnestic mild cognitive impairment(aMCI), Alzheimer disease(AD) and normal control group. Methods: Normal scanning, 1H-MRS of VOI are acquired by Siemens Novus 1.5T MRI system. A 1H-MRS was performed in the bilateral medial temporal lobes(MITS) and left posterior cingulated contex(PCC) of the 12 aMCI patients, 12 AD patients and 12 healthy age and sex-matched controls using single voxel sequence mode(SVS-SE-30). The ratios of NAA/Cr, Cho/Cr, mI/Cr, NAA/mI and metabolite asymmetries were compared among the groups. Results: NAA/Cr of left medial temporal lobe in the aMCI and AD groups were lower than that of the NC group with statistical significance(P<0.05), AD group and the aMCI group had no statistically significant difference(P>0.05); NAA/mI in aMCI and AD group was lower than that in the NC group with statistical significance(P<0.05). There was no statistically significant difference in AD group and the aMCI group(P>0.05). NAA/mI of right medial temporal lobe in AD and aMCI group was lower than that of the NC group with statistical significance(P<0.05). There were no statistical significance of NAA/Cr, Cho/Cr, mI/Cr and NAA/mI located in left posterior cingulate gyrus of aMCI, AD and NC groups. Metabolites asymmetry index of two sides of medial temporal lobe of aMCI group and NC group had statistically significant difference(P<0.05), metabolites asymmetry index of other position had no significant difference. Conclusion: The changes of NAA/Cr in the left medial temporal lobe play an important role in differential diagnosis of aMCI, AD and NC; the reduction of NAA/mI in bilateral medial temporal lobes is earlier than NAA/Cr in aMCI due to the reason that hyperplasia of neuroglial is earlier than the loss of neurons. 1H-MRS is a useful method in monitoring, diagnosis and differential diagnosis of aMCI, AD and NC.
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Received: 12 June 2010
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2011, Vol. 22 
