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| Study the relationship between the expression of Annexin A7 and CT ofnasopharyngeal carcinoma |
| YANG Min-zheng1, LIANG Qing-mo2 |
| 1.Yongzhou Hospital, Yongzhou Hunan 425006, China; 2.Affiliated Nanhua Hospital,University of South China, Hengyang Hunan 421001, China |
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Abstract Objective: To study the relationship between the expression of Annexin A7 and CT of nasopharyngeal carcinoma(NPC). Methods: Fifty-eight cases of NPC, 20 cases of lymph node metastatic NPC(LMNPC) and 24 cases of chronic rhinitis(CR) were all performed immunochemistry to detect the expression of Annexin A7. All patients of NPC had axial CT scan and some of the cases had coronal CT scan and contrast enhancement. Results: The positive ratio of Annexin A7 was 87.9%(51/58), 95.0%(19/20) and 41.7%(10/24) in NPC, LMNPC and CR, respectively. The expression of Annexin A7 were higher in LMNPC than NPC, in NPC than CR(P＜0.05). There was correlation of expression of Annexin A7 to differentiation, region of metastasis, lymph node metastasis, distant metastasis and clinical stage(P＜0.05), but no correlation to age and gender. There were correlation among the expression of Annexin A7 to invasion of posterior nares, pharynx oralis and bone destruction of base of skull, cervical lymph node metastasis showed in CT(P＜0.05). Conclusion: There was relationship of the expression of Annexin A7 to differentiation, invasive depth and destruction of base of skull of NPC. And serve as the index of malignancy degree of CT and prognosis of NPC.
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Received: 13 May 2010
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2011, Vol. 22 
