心肌延迟对比增强MR评估肺高血压患者心肌受损及其#br#
与心功能的相关性

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Abstract Objective: To assess the extent of myocardial damage and its impact on cardiac function in patients with pulmonary hypertension(PH) using myocardial delayed contrast enhancement(DCE) MR imaging. Methods: Sixty patients with PH were confirmed by cardiac catheterization and all patients underwent MR imaging, 8 males and 52 females, aged (39.9±12.5) years. Right ventricle(RV) and left ventricle(LV) volumes, ejection fraction(EF), stroke volume(SV), mass, fractional distance change from septum to free-wall(fractional-SFD), fractional tricuspid annulus apex distance change(fractional-TAAD), curvature of interventricular septum(CIVS), and curvature ratio(RC) were obtained by steady-state free precession sequence(FIESTA) images. RV and LV volumes, SV, mass were corrected by body surface area(BSA). Ventricular mass index(VMI) was the ratio of RVMM and LVMM. DCE images were post-processed for calculating DCE MM. Location and characteristics of myocardial DCE were also observed and analyzed. Independent Sample t-Test or Mann-Whitney U Test was used to compare the differences of ventricular function parameters in patients with and without DCE. Results: DCE was present in 49 patients(81.67%). DCE was confined to the RV insertion points(RVIPs) in 12 patients(24.49%), and extended into the interventricular septum(IVS) in 37 patients(75.51%). DCE was present both anterior and inferior in 43 patients(87.76%). DCE was limited to the mid-wall region of the ventricular myocardium. DCE MM was (3.83±1.93)g, 2.88%(0.25%~6.50%) of the total mass of both RV and LV. Compared with patients without DCE, RV ESVI and VMI of patients with DCE were significantly increased(P=0.040, 0.011), while RV EF, fractional-TAAD, CIVS and RC was significantly decreased(P=0.002, 0.001, 0.023, 0.001). Conclusion: Myocardial DCE can be used as a reference index to evaluate the severity of cardiac function damage in patients with PH.

Key words： Hypertension, pulmonary Myocardium Magnetic resonance imaging

Received: 30 September 2015

PACS:	Ｒ541.3
	Ｒ445.2

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	Articles by authors
	YU Ya-nan
	LU Qing-qing
	HAN Yan
	CUI Qian
	YU Tie-lian
	LI Dong

Cite this article:

YU Ya-nan,LU Qing-qing,HAN Yan, et al. Evaluation of myocardial damage and its correlation with cardiac function in patients with pulmonary hypertension by myocardial delayed contrast enhancement MR imaging[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2016, 27(5): 345-348.

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http://www.jccmi.com.cn/EN/ OR http://www.jccmi.com.cn/EN/Y2016/V27/I5/345

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