酸刺激前后扩散加权成像评价干燥综合征患者腮腺功能

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Abstract Objective: To investigate the value of MR diffusion-weighted imaging(DWI) for evaluating the function of parotid glands in patients with Sj?觟gren’s syndrome(SS) before and after acid stimulation. Methods: Fourteen patients with SS(patient group) and age and sex-matched 12 healthy volunteers(control group) were examined with parotid gland conventional sequences and DWI sequence before acid stimulation. After the acid stimulation with Vc pill 200 mg, DWI sequence was repeated 15 times, interval 2.5 min. We compared the difference between the two groups in resting state; then compared the changes of ADC values after stimulation. Results: The ADC values of the patient group were lower than that of the control group before stimulation((0.77±0.15)×10-3 mm2/s and (0.93±0.28)×10-3 mm2/s, respectively, P＜0.05). The ADC values of the control group increased rapidly after stimulation, then reached the peak gradually. The ADC values of the patient group decreased rapidly after stimulation, then increased to the peak slowly. The time to peak(Tmax) of the patient group was later than that of the control group(27.5 min and 22.5 min, respectively, P＜0.05), the peak value and change rate were lower than that of the control group(P＜0.05). Conclusion: The ADC values of parotid glands in patients with SS decreased, and changed with time after acid stimulation, which were different from that in healthy control group. MR DWI can evaluate the function of parotid glands in patients with SS before and after acid stimulation.

Key words： Sjogren’s syndrome Parotid diseases Magnetic resonance imaging

Received: 29 December 2015

PACS:	Ｒ442.8
	Ｒ781.7
	Ｒ445.2

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	XING Xiao-fei
	DING Chang-wei

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XING Xiao-fei,DING Chang-wei. Parotid glands function evaluated by MR diffusion-weighted imaging with acid stimulation in Sj?觟gren’s syndrome[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2016, 27(10): 706-709.

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http://www.jccmi.com.cn/EN/ OR http://www.jccmi.com.cn/EN/Y2016/V27/I10/706

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