磁共振扩散加权成像在预测乳腺癌肝转移早期疗效中的作用

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Abstract Objective: To determine whether change of apparent diffusion coefficient(ADC) values could predict early response to chemotherapy in breast cancer liver metastases(BCLM). Methods: We retrospectively studied 42 patients with BCLMs(86 lesions) who had undergone conventional MRI and DWI at 3 days before chemotherapy and 1 week, 2 weeks, 4 weeks after chemotherapy. Selected patients were divided into responders(R) and non-responders(NR). The grouping reference was based on MRI according to response evaluation criteria in solid tumors(RECIST). Results: Eighty-six metastases were classified as 40 R and 46 NR. The difference in maximum tumor diameter of R group between pre-chemotherapy and 4 weeks after chemotherapy was significant(P<0.05). Pretreatment mean ADC((1.06±0.07)×10-3 mm2/s) of R group was significantly lower than that of NR group((1.22±0.14)×10-3 mm2/s)(P<0.05). After 1 week of chemotherapy, the mean ADC of R group increased slightly and the mean ADC of NR group decreased slightly, with no statistical significance. After 2 weeks and 4 weeks of chemotherapy, the mean ADC of R group increased significantly but not in NR group. The results of ROC curve showed that areas of under the curve were 0.846, pretreatment ADC of 1.11×10-3 mm2/s concluded BCLMs to chemotherapy ineffective sensitivity and specificity value were 78.3% and 87.5%, respectively. Conclusion: The pretreatment and 2 weeks after treatment ADC value may be helpful to predict early response to chemotherapy in BCLM.

Key words： Breast neoplasms Liver neoplasms Neoplasms metastasis Magnetic resonance imaging

Received: 09 August 2016

PACS:	Ｒ737.9
	Ｒ735.7
	Ｒ445.2

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	Articles by authors
	WANG Ya-ting
	ZHU Yan
	GUO Li-li
	SHI Yu-zhen
	CHEN Wei
	BAI Gen-ji

Cite this article:

WANG Ya-ting,ZHU Yan,GUO Li-li, et al. Prediction of early response to chemotherapy in breast cancer liver metastases by DWI[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2017, 28(3): 180-183.

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http://www.jccmi.com.cn/EN/ OR http://www.jccmi.com.cn/EN/Y2017/V28/I3/180

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