1H-MRS测量颞叶癫痫患者海马代谢物浓度变化的研究

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Abstract Objective: To measure the changes of bilateral hippocampal metabolite concentrations in patients with temporal lobe epilepsy(TLE) by using proton magnetic resonance spectroscopy(1H-MRS). The main metabolites that we studied include N-acetylaspartate(NAA), γ-aminobutyric acid(GABA) and glutamate/glutamine compounds(GLx). These changes of the metabolite concentrations can make us further understand the pathogenesis of epilepsy, and provide more imaging support for locating the epileptic foci in TLE. Methods: Ten patients with TLE and 14 normal controls were studied. All subjects underwent bilateral hippocampal conventional MRI and 1H-MRS scans. The metabolite concentrations of NAA, Cr, Cho, GABA and GLx in the ipsilateral hippocampus were compared with the concentrations in the contralateral hippocampus and the normal control group. Results: NAA was significantly lower in the ipsilateral hippocampus than in the contralateral hippocampus and normal control group(P=0.001, P=0.007, respectively). By partial correlation analysis with the controlling factors of age, GLx and NAA were negatively correlated(P=0.016), and GABA and GLx are negatively correlated(P=0.024) in the ipsilateral hippocampus. Conclusion: NAA reduced in ipsilateral hippocampus in patients with temporal lobe epilepsy, which can provide the basis for the localization of epileptic foci. GABA and GLx in ipsilateral hippocampus have different changes compared with the normal control group with a negative correlation in metabolic changes, the local variations may be related with seizure and treatment status of epilepsy.

Key words： Epilepsy, frontal lobe Hippocampus Magnetic resonance imaging

Received: 10 November 2016

PACS:	Ｒ742.1
	Ｒ445.2

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	Articles by authors
	AN Yang1
	SUN Hai-zhen1
	NI Hong-yan2
	YIN Jian-zhong2

Cite this article:

AN Yang1,SUN Hai-zhen1,NI Hong-yan2, et al. Study of changes of hippocampal metabolite concentrations in patients with temporal lobe epilepsy using 1H-MRS[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2017, 28(7): 457-461.

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http://www.jccmi.com.cn/EN/ OR http://www.jccmi.com.cn/EN/Y2017/V28/I7/457

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